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Quinine hemisulfate salt monohydrate

SIAL/22642 - tested according to Ph. Eur.

Synonym: Chinini sulfas

CAS Number: 207671-44-1
Empirical Formula (Hill Notation): C20H24N2O2 · 0.5H2O4S · H2O
Molecular Weight: 391.47
MDL Number: MFCD00150790
Linear Formula: C20H24N2O2 · 0.5H2O4S · H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-22642-50G 50 g
 $976.00
1/EA		 Add To Favorites

 

agency tested according to Ph. Eur.
  USP/NF
antibiotic activity spectrum parasites
InChI 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
InChI key ZHNFLHYOFXQIOW-LPYZJUEESA-N
mode of action enzyme | inhibits
mp ~225 °C (dec.) (lit.)
Quality Level 100 
SMILES string O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
Application: Quinine hemisulfate salt monohydrate has been used as a tastant for testing the saccharin and quinine consumption in wild-type or knock-in mice. It has been used for studying the toxicity of heme (FP)-complexes.
Biochem/physiol Actions: Potassium channel blocker. Antimalarial
Biochem/physiol Actions: Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Biochem/physiol Actions: Quinine hemisulfate is an alkaloid originally isolated from the Cinchona family of South American trees. It inhibits mitochondrial ATP-regulated potassium channel and posssess antimalarial, anticholinergic, antihypertensive and hypoglycemic properties.
mp ~225 °C (dec.) (lit.)
UNSPSC 12352210

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