N,N-Dimethylformamide
SIAL/227056 - anhydrous, 99.8%
Synonym: DMF; NSC 5356
CAS Number: 68-12-2
Empirical Formula (Hill Notation): C3H7NO
Molecular Weight: 73.09
EC Number: 200-679-5
MDL Number: MFCD00003284
Linear Formula: HCON(CH3)2
Product Type: Chemical
| assay | 99.8% |
| autoignition temp. | 833 °F |
| bp | 153 °C (lit.) |
| density | 0.944 g/mL (lit.) |
| evapn. residue | <0.0005% |
| expl. lim. | 15.2 % |
| form | liquid |
| grade | anhydrous |
| impurities | <0.005% water |
| InChI | 1S/C3H7NO/c1-4(2)3-5/h3H, |
| InChI key | ZMXDDKWLCZADIW-UHFFFAOYSA |
| mp | −61 °C (lit.) |
| pH | 7 (20 °C, 200 g/L) |
| Quality Level | 300  |
| refractive index | n |
| SMILES string | [H]C(=O)N(C)C |
| vapor density | 2.5 (vs air) |
| vapor pressure | 2.7 mmHg ( 20 °C) |
| Application: | N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfi |
| Application: | DMF has been used as a solvent in the following processes: • Multi-step synthesis of L-azidohomoalanine (L-Aha) during the substitution of the mesylate by sodium azide. • Synthesis of phosphine-FLAG®, a detection reagent for metabolic labeling of glycans. • Synthesis of per-O-acetylated 6-azidofucose, a per-O-acetylated azido sugar. |
| Application: | Solvent for many hydrophobic organic compounds. |
| General description: | N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups. |
| General description: | N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions. |
| Legal Information: | FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | 1, 6×1, 2, 4×2 L in Sure/Seal™ |
| Packaging: | 100, 12×100 mL in Sure/Seal™ |
| Packaging: | 18, 200 L in Pure-Pac™ 1 |
| Packaging: | View returnable container options . |
| Symbol |    GHS02,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H226 - H312 + H332 - H319 - H360D |
| Precautionary statements | P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61-20/21-36 |
| Safety Statements | 53-45 |
| RIDADR | UN 2265 3 / PGIII |
| WGK Germany | WGK 2 |
| Flash Point(F) | 135.5 °F - closed cup |
| Flash Point(C) | 57.5 °C - closed cup |
| Purity | 99.8% |
| bp | 153 °C (lit.) |
| mp | −61 °C (lit.) |
| Density | 0.944 g/mL (lit.) |
| Refractive Index | n |
| UNSPSC | 12352111 |