p-Toluenesulfonyl chloride
SIAL/240877 - ReagentPlus®, ≥99%
Synonym: TsCl; Tosyl chloride
CAS Number: 98-59-9
Empirical Formula (Hill Notation): C7H7ClO2S
Molecular Weight: 190.65
EC Number: 202-684-8
MDL Number: MFCD00007450
Linear Formula: CH3C6H4SO2Cl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: 240877-100G
This image depicts SKU: 240877-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 240877-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: 240877-500G
This image depicts SKU: 240877-500G
| assay | ≥99% |
| bp | 134 °C/10 mmHg (lit.) |
| form | solid |
| InChI | 1S/C7H7ClO2S/c1-6-2-4-7(5 |
| InChI key | YYROPELSRYBVMQ-UHFFFAOYSA |
| mp | 65-69 °C (lit.) |
| product line | ReagentPlus® |
| Quality Level | 200  |
| SMILES string | Cc1ccc(cc1)S(Cl)(=O)=O |
| solubility | benzene: freely soluble(lit.) |
| chloroform: freely soluble(lit.) | |
| ethanol: freely soluble(lit.) | |
| water: insoluble(lit.) | |
| vapor pressure | 1 mmHg ( 88 °C) |
| Application: | p-Toluenesulfonyl chloride may be used in the following processes: • In combination with N-methylimidazole for the esterification or thioesterification of carboxylic acids and alcohols or thiols. • As an additive to enhance the yield of symmetrical biaryls via palladium chloride catalyzed homo-coupling of arylboronic acids in the absence of ligands. • As a positive chlorine source for the ?-chlorination of ketones. • Solvent-free tosylation of alcohols and phenols in the presence of heterodoxy acids. • As an activator for reaction between 2-alkynylbenzaldoxime and phenols to form 1-aroxyisoquinolines in the presence of silver triflate. • As a catalyst for the solvent-free preparation of symmetrical bis(benzhydryl)ethers from benzhydrols. |
| General description: | p-Toluenesulfonyl chloride is an organic sulfonyl chloride mainly used to convert hydroxyl groups into good leaving group by forming sulfonates. |
| Legal Information: | ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | 100, 500 g in poly bottle |
| Packaging: | 5 g in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H290 - H315 - H317 - H318 |
| Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Codes | Xi |
| Risk Statements | 38-41 |
| Safety Statements | 26-39 |
| RIDADR | UN 3261 8 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 262.4 °F |
| Flash Point(C) | 128 °C |
| Purity | ≥99% |
| bp | 134 °C/10 mmHg (lit.) |
| mp | 65-69 °C (lit.) |
| UNSPSC | 12352100 |