Magnesium stearate
SIAL/26454 - puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)
Synonym: Stearic acid magnesium salt
CAS Number: 557-04-0
Empirical Formula (Hill Notation): C36H70MgO4
Molecular Weight: 591.24
EC Number: 209-150-3
MDL Number: MFCD00036391
Linear Formula: [CH3(CH2)16CO2]2Mg
Product Type: Chemical
| acid value | 195‑210(fatty acid) |
| anion traces | chloride (Cl-): ≤1000 mg/kg |
| sulfate (SO42-): ≤5000 mg/kg | |
| application(s) | pharmaceutical (small molecule) |
| assay | ≥40% stearic acid basis (GC) |
| ≥90% stearic and palmitic acid basis | |
| 4.0-5.0% Mg basis (calc on dry sub.) | |
| cation traces | Cd: ≤3 mg/kg |
| Ni: ≤5 mg/kg | |
| Pb: ≤10 mg/kg | |
| grade | puriss. |
| impurities | acidity or alkalinity, complies |
| microbiological impurity, in accordance | |
| residual solvents, complies | |
| InChI | 1S/2C18H36O2.Mg/c2*1-2-3- |
| InChI key | HQKMJHAJHXVSDF-UHFFFAOYSA |
| loss | ≤6.0% loss on drying, 105 °C |
| mp | 200 °C (lit.) |
| quality | meets analytical specification of Ph. Eur., BP |
| SMILES string | CCCCCCCCCCCCCCCCCC(=O)O[M |
| solubility | alcohol: insoluble |
| diethyl ether: insoluble | |
| water: insoluble | |
| suitability | in accordance for fatty acid composition |
| passes test for identity |
| Application: | Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules. |
| Biochem/physiol Actions: | Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥40% stearic acid basis (GC); ≥90% stearic and palmitic acid basis; 4.0-5.0% Mg basis (calc on dry sub.) |
| mp | 200 °C (lit.) |
| UNSPSC | 12352106 |