Salicylic acid
SIAL/27301 - meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance)
Synonym: 2-Hydroxybenzoic acid
CAS Number: 69-72-7
Empirical Formula (Hill Notation): C7H6O3
Molecular Weight: 138.12
EC Number: 200-712-3
MDL Number: MFCD00002439
Linear Formula: 2-(HO)C6H4CO2H
Product Type: Chemical
| anion traces | chloride (Cl-): ≤50 mg/kg |
| sulfate (SO42-): ≤200 mg/kg | |
| application(s) | pharmaceutical (small molecule) |
| assay | 99.5-100.5% (calc. to the dried substance) |
| bp | 211 °C (lit.) |
| ign. residue | ≤0.05% (as SO4) |
| impurities | residual solvents, complies |
| ≤0.001% heavy metals (as Pb) | |
| ≤0.2% related subst. (HPLC) | |
| InChI | 1S/C7H6O3/c8-6-4-2-1-3-5( |
| InChI key | YGSDEFSMJLZEOE-UHFFFAOYSA |
| loss | ≤0.3% loss on drying |
| mp | 158-161 °C |
| 158-161 °C (lit.) | |
| quality | meets analytical specification of Ph. Eur., BP, USP |
| Quality Level | 200  |
| SMILES string | OC(=O)c1ccccc1O |
| suitability | complies for appearance of solution |
| complies for identity | |
| vapor density | 4.8 (vs air) |
| vapor pressure | 1 mmHg ( 114 °C) |
| Application: | • Salinity stress management in agriculture: A study demonstrated the application of salicylic acid in ameliorating salinity stress in barley, revealing its potential to enhance crop resilience to saline environments, thereby contributing to sustainable agricultural practices (Hanif et al., 2024  ).• Enhanced pharmaceutical gel performance: Research on nitrocellulose for prolonged permeation of Levofloxacin HCl-Salicylic Acid In Situ gel emphasized its utility in enhancing drug delivery systems, particularly in treating bacterial infections with improved efficacy (Khaing et al., 2024 ).• Biotechnological production of withanolides: Salicylic acid was applied as an elicitor in the hairy root culture of Withania somnifera, significantly boosting the production of withanolides and phenolic acids, vital for pharmaceutical applications due to their therapeutic properties (Halder and Ghosh, 2024 ). |
| Symbol |    GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H318 - H361d |
| Precautionary statements | P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 314.6 °F - closed cup |
| Flash Point(C) | 157 °C - closed cup |
| Purity | 99.5-100.5% (calc. to the dried substance) |
| bp | 211 °C (lit.) |
| mp | 158-161 °C (lit.); 158-161 °C |
| UNSPSC | 12352100 |