(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide

SIAL/29208 - for protein sequence analysis (by MALDI-MS), ≥98.5%

Synonym: N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide; TMPP-Ac-OSu

CAS Number: 226409-58-1
Empirical Formula (Hill Notation): C₃₃H₃₉BrNO₁₃P
Molecular Weight: 768.54
MDL Number: MFCD03095505
Linear Formula: C₃₃H₃₉BrNO₁₃P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-29208-50MG	50 mg	$286.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98.5%
	≥98.5% (HPLC)
grade	for protein sequence analysis (by MALDI-MS)
InChI	1S/C33H39NO13P.BrH/c1-38-19-12-22(41-4)31(23(13-19)42-5)48(18-30(37)47-34-28(35)10-11-29(34)36,32-24(43-6)14-20(39-2)15-25(32)44-7)33-26(45-8)16-21(40-3)17-27(33)46-9;/h12-17H,10-11,18H2,1-9H3;1H/q+1;/p-1
InChI key	YKMSQZIYVKTUHI-UHFFFAOYSA-M
mp	199-205 °C (dec.)
Quality Level	100
SMILES string	[Br-].COc1cc(OC)c(c(OC)c1)[P+](CC(=O)ON2C(=O)CCC2=O)(c3c(OC)cc(OC)cc3OC)c4c(OC)cc(OC)cc4OC
storage temp.	−20°C
technique(s)	MALDI-MS: suitable

Application:	TMPP-Ac-OSu was used for labelling peptides, in tandem mass spectrometry, done for converting arginine to ornithine, in order to improve the fragmentation pattern of peptides.
General description:	N-Succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP-Ac-OSu) is an acylating reagent, and is generally used for the selective derivatization of N-terminal a-amino group of peptide. The TMPP-acetylated peptides undergo fragmentation thereby creating a-type ions, thus obtaining sequence information becomes easier, even without the usage of automated computational approach. It can be used as a labelling reagent in liquid chromatography-coupled mass spectrometry (LC-MS/MS) of N-terminal peptides, so as to improve ionization efficiency, simplify fragmentation, and retention times, thereby leading to better separation of peptides.
Other Notes:	Reagent for modifying N-termial of peptides for fast atom bombardment, FAB or matrix assisted laser desorption/ionization MS, MALDI MS
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98.5% (HPLC); ≥98.5%
mp	199-205 °C (dec.)
Storage Temp.	−20°C
UNSPSC	41116105

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