Acetic anhydride
SIAL/320102 - ReagentPlus®, ≥99%
Synonym: Acetanhydride; Acetic acid anhydride; Acetyl acetate; Acetyl anhydride; Acetyl anhydride; Ethanoic anhydride
CAS Number: 108-24-7
Empirical Formula (Hill Notation): C4H6O3
Molecular Weight: 102.09
EC Number: 203-564-8
MDL Number: MFCD00008705
Linear Formula: (CH3CO)2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 320102-100ML.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 320102-1L.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 320102-500ML.
| assay | ≥99% |
| autoignition temp. | 629 °F |
| bp | 138-140 °C (lit.) |
| density | 1.08 g/mL (lit.) |
| expl. lim. | 10.3 % |
| form | liquid |
| functional group | anhydride |
| ester | |
| InChI | 1S/C4H6O3/c1-3(5)7-4(2)6/ |
| InChI key | WFDIJRYMOXRFFG-UHFFFAOYSA |
| mp | −73 °C (lit.) |
| product line | ReagentPlus® |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | CC(=O)OC(C)=O |
| solubility | water: slightly soluble |
| vapor density | 3.5 (vs air) |
| vapor pressure | 10 mmHg ( 36 °C) |
| 4 mmHg ( 20 °C) |
| Application: | Acetic anhydride may be used as a reactant to synthesize: • 3-acetoxybenzoic acid by reacting with 3-hydroxybenzoic acid • 6-dimethylamino-2,3-nap |
| Application: | Acetic anhydride was used in the following studies: • Lipozyme TL IM (commercial immobilized lipase from Thermomyces lanuginosus) catalyzed acetylation of essential clove oil. • As acetyl donor to investigate the lipase catalyzed acetylation of nanofibrillated cellulose (NFC). • Synthesis of N-substituted pyrazolines. • Acetylation of Barnyardgrass (Echinochloa crus-galli) starch. |
| General description: | Acetic anhydride is a carboxylic acid anhydride commonly used as an acetylating agent for amines and alcohols. |
| General description: | Acetic anhydride participates in the Friedel-Craft′s intramolecular cyclization reaction of cyclopropyl ketones to afford the tetralones. It has been reported to promote the Knoevenagel condensation of various aldehydes and activated methylene compounds. |
| Legal Information: | ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | 1 L in glass bottle |
| Packaging: | 100, 4×100, 500 mL in glass bottle |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H226 - H302 - H314 - H330 |
| Precautionary statements | P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 10-20/22-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1715 3(8) / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 120.2 °F - closed cup |
| Flash Point(C) | 49 °C - closed cup |
| Supplemental Hazard Statements | EUH071 |
| Purity | ≥99% |
| bp | 138-140 °C (lit.) |
| mp | −73 °C (lit.) |
| Density | 1.08 g/mL (lit.) |
| Refractive Index | n |
| UNSPSC | 12352100 |