Acetic anhydride
SIAL/320102 - ReagentPlus®, ≥99%
Synonym: Acetanhydride; Acetic acid anhydride; Acetyl acetate; Acetyl anhydride; Acetyl anhydride; Ethanoic anhydride
CAS Number: 108-24-7
Empirical Formula (Hill Notation): C4H6O3
Molecular Weight: 102.09
EC Number: 203-564-8
MDL Number: MFCD00008705
Linear Formula: (CH3CO)2O
Product Type: Chemical
4×100 Slip-cover Can
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| assay | ≥99% |
| autoignition temp. | 629 °F |
| bp | 138-140 °C (lit.) |
| density | 1.08 g/mL (lit.) |
| expl. lim. | 10.3 % |
| form | liquid |
| InChI | 1S/C4H6O3/c1-3(5)7-4(2)6/ |
| InChI key | WFDIJRYMOXRFFG-UHFFFAOYSA |
| mp | −73 °C (lit.) |
| product line | ReagentPlus® |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | CC(=O)OC(C)=O |
| solubility | water: slightly soluble |
| vapor density | 3.5 (vs air) |
| vapor pressure | 10 mmHg ( 36 °C) |
| 4 mmHg ( 20 °C) |
| Application: | Acetic anhydride may be used as a reactant to synthesize: • 3-acetoxybenzoic acid by reacting with 3-hydroxybenzoic acid • 6-dimethylamino-2,3-nap |
| Application: | Acetic anhydride was used in the following studies: • Lipozyme TL IM (commercial immobilized lipase from Thermomyces lanuginosus) catalyzed acetylation of essential clove oil. • As acetyl donor to investigate the lipase catalyzed acetylation of nanofibrillated cellulose (NFC). • Synthesis of N-substituted pyrazolines. • Acetylation of Barnyardgrass (Echinochloa crus-galli) starch. |
| General description: | Acetic anhydride is a carboxylic acid anhydride commonly used as an acetylating agent for amines and alcohols. |
| General description: | Acetic anhydride participates in the Friedel-Craft′s intramolecular cyclization reaction of cyclopropyl ketones to afford the tetralones. It has been reported to promote the Knoevenagel condensation of various aldehydes and activated methylene compounds. |
| Legal Information: | ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC |
| Packaging: | 1 L in glass bottle |
| Packaging: | 100, 4×100, 500 mL in glass bottle |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H226 - H302 - H314 - H330 |
| Precautionary statements | P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 10-20/22-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1715 3(8) / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 120.2 °F - closed cup |
| Flash Point(C) | 49 °C - closed cup |
| Supplemental Hazard Statements | EUH071 |
| Purity | ≥99% |
| bp | 138-140 °C (lit.) |
| mp | −73 °C (lit.) |
| Density | 1.08 g/mL (lit.) |
| Refractive Index | n |
| UNSPSC | 12352100 |