Potassium clavulanate

SIAL/33454 - VETRANAL^®, analytical standard

Synonym: Clavulanate potassium

CAS Number: 61177-45-5
Empirical Formula (Hill Notation): C₈H₈NO₅K
Molecular Weight: 237.25
EC Number: 262-640-9
MDL Number: MFCD01710901
Linear Formula: C₈H₈NO₅K
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-33454-100MG	100 mg	$199.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	agriculture clinical environmental forensics and toxicology pharmaceutical (small molecule)
format	neat
grade	analytical standard
InChI	1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
InChI key	ABVRVIZBZKUTMK-JSYANWSFSA-M
product line	VETRANAL^®
Quality Level	200
shelf life	limited shelf life, expiry date on the label
SMILES string	[K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(O2)=CCO
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	The analytical standard can be used as follows:• Simultaneous analysis of amoxicillin and clavulanate potassium in pharmaceutical formulations by capillary electrophoresis (CE) combined with capacitively coupled contactless conductivity detection (C⁴D) • Development of a stability-indicating high-performance liquid chromatographic (HPLC) method combined with mass spectrometry (MS) to measure amoxicillin, clavulanate potassium, and their impurities in their combined dosage forms • Residue analysis of potassium clavulanate and amoxicillin trihydrate by a UV spectrophotometric method in their bulk, combined tablet formulations, and human urine samples • HPLC method-based determination of meropenem and potassium clavulanate in the presence of their degradation impurities in intravenous solutions in combination with a diode array detector (DAD) • Determination of amoxicillin and clavulanic acid by capillary zone electrophoresis (CZE) in their combined commercial formulations
Biochem/physiol Actions:	β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
General description:	Potassium clavulanate is an oxapenam derivative and belongs to the group of β-lactamase inhibitors. It is used in combination with the penicillin group of antibiotics to give them resistance to β-lactamase.
Legal Information:	VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Symbol	GHS02,GHS08
Signal word	Danger
Hazard statements	H228 - H252 - H317 - H334
Precautionary statements	P210 - P235 - P280 - P302 + P352 - P304 + P340 + P312 - P403 + P235
Hazard Codes	F,Xn
Risk Statements	11-36-42/43-44
Safety Statements	8-16-22-26-36/37-45
RIDADR	UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., H
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable
Supplemental Hazard Statements	EUH014 - EUH044

Storage Temp.	2-8°C
UNSPSC	41116107

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