Clotrimazole
SIAL/33894 - VETRANAL®, analytical standard
Synonym: 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; 1-(o-
CAS Number: 23593-75-1
Empirical Formula (Hill Notation): C22H17ClN2
Molecular Weight: 344.84
EC Number: 245-764-8
MDL Number: MFCD00057220
Linear Formula: C22H17ClN2
Product Type: Chemical
antibiotic activity spectrum | fungi |
application(s) | agriculture environmental |
format | neat |
grade | analytical standard |
InChI | 1S/C22H17ClN2/c23-21-14-8 |
InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA |
mode of action | protein synthesis | interferes |
product line | VETRANAL® |
Quality Level | 100 |
shelf life | limited shelf life, expiry date on the label |
SMILES string | Clc1ccccc1C(c2ccccc2)(c3c |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable |
Application: | Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method. |
Application: | Clotrimazole may be used as an analytical reference standard for the determination of the analyte in: • Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC). • Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). |
Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
General description: | Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis. |
General description: | Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane. |
Legal Information: | VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH |
Symbol | GHS07,GHS09 |
Signal word | Warning |
Hazard statements | H302 - H315 - H319 - H410 |
Precautionary statements | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xn |
Risk Statements | 22-36/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
UNSPSC | 41116107 |