Rapamycin

SIAL/37094 - VETRANAL^®, analytical standard

Synonym: Sirolimus

CAS Number: 53123-88-9
Empirical Formula (Hill Notation): C₅₁H₇₉NO₁₃
Molecular Weight: 914.17
MDL Number: MFCD00867594
Linear Formula: C₅₁H₇₉NO₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-37094-10MG	10 mg	$595.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	forensics and toxicology pharmaceutical (small molecule)
format	neat
grade	analytical standard
InChI	1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key	QFJCIRLUMZQUOT-HPLJOQBZSA-N
product line	VETRANAL^®
Quality Level	100
shelf life	limited shelf life, expiry date on the label
SMILES string	CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
storage temp.	−20°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	The analytical standard can be used as follows:• Electrochemical determination of rapamycin using boron-doped diamond electrode and differential pulse voltammetry (DPV) in human urine, serum, and blood samples • Simultaneous determination of six immunosuppressants from whole blood samples by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) technique combined with modified QuEChERS method
General description:	Rapamycin belongs to the macrolide class of antibiotics obtained from the bacterium Streptomyces hygroscopicus. It was first used as an anti-fungal agent but later also found use as an immunosuppressant and potential anti-cancer drug. It acts by preventing the activity of serine/threonine kinase and subsequently blocking the cytokine-driven T cell proliferation.
Legal Information:	VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH
Other Notes:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Symbol	GHS08
Signal word	Warning
Hazard statements	H351 - H361fd
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

Storage Temp.	−20°C
UNSPSC	41116107

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