Staurosporine

SIAL/37095 - VETRANAL^®, analytical standard

CAS Number: 62996-74-1
Empirical Formula (Hill Notation): C₂₈H₂₆N₄O₃
Molecular Weight: 466.53
MDL Number: MFCD00077402
Linear Formula: C₂₈H₂₆N₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-37095-10MG	10 mg	$2100.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	forensics and toxicology pharmaceutical (small molecule)
format	neat
grade	analytical standard
InChI	1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
InChI key	HKSZLNNOFSGOKW-ZGQXJOJZSA-N
product line	VETRANAL^®
Quality Level	100
shelf life	limited shelf life, expiry date on the label
SMILES string	CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
storage temp.	−20°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	Protein Painting for Structural Analysis: This research utilizes staurosporine′s role in protein kinase inhibition to develop a technique called protein painting, which is essential for structural and binding site analysis. This approach enhances understanding of protein interactions and can be pivotal in drug design, particularly in targeting specific kinase enzymes in cancer research (Zheng Z et al., 2024 ). Identification of Anthelmintic Activities: Staurosporine is employed to identify small molecule inhibitors that target conserved proteins among gastrointestinal nematodes. This study not only highlights its role in parasitic infection treatments but also its broader applications in developing antiparasitic drugs, leveraging its properties as a potent kinase inhibitor (Jung H et al., 2024 ). Development of Novel Cytoprotective Compounds: Focusing on mitochondria-dependent cell death, this research explores staurosporines potential to inhibit pathways involved in cellular apoptosis. This is particularly crucial in developing therapeutic strategies against diseases characterized by unwanted cell death, such as neurodegenerative diseases and certain types of cancer (Matsuyama M et al., 2023 ).
General description:	Staurosporine belongs to the class of indolocarbazole alkaloids and shows anti-fungal and anti-oomycete activities. It is isolated from Streptomyces sp. and is known to be a broad-spectrum inhibitor of protein kinase.
Legal Information:	VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Symbol	GHS08
Signal word	Warning
Hazard statements	H361d - H413
Precautionary statements	P201 - P202 - P273 - P280 - P308 + P313 - P405
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	41116107

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