DIC
SIAL/38370 - purum, ≥98.0% (GC)
Synonym: N,N′-Diisopropylcarbodiimide
CAS Number: 693-13-0
Empirical Formula (Hill Notation): C7H14N2
Molecular Weight: 126.20
EC Number: 211-743-7
MDL Number: MFCD00065689
Linear Formula: (CH3)2CHN=C=NCH(CH3)2
Product Type: Chemical
application(s) | peptide synthesis |
assay | ≥98.0% (GC) |
bp | 145-148 °C (lit.) |
density | 0.815 g/mL at 20 °C |
0.815 g/mL at 20 °C (lit.) | |
form | liquid |
grade | purum |
InChI | 1S/C7H14N2/c1-6(2)8-5-9-7 |
InChI key | BDNKZNFMNDZQMI-UHFFFAOYSA |
Quality Level | 200 ![]() |
reaction suitability | reaction type: Coupling Reactions |
refractive index | n |
SMILES string | CC(C)N=C=NC(C)C |
Application: | N,N′-Diisopropylcarbodiimide can be used: • To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes. • To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines. • To synthesize 1-isopropyl-2-alkoxycarbo |
Application: | Alternative to dicyclohexylcarbodiimide in peptide synthesis. |
Application: | DIC can be used as: • A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively. • A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction. • A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea. |
General description: | N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator. |
Symbol | ![]() ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H226 - H317 - H318 - H330 - H334 |
Precautionary statements | P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
Hazard Codes | T+ |
Risk Statements | 10-26-37/38-41-42/43 |
Safety Statements | 26-36/37/39-45 |
RIDADR | UN 2929 3(6.1) / PGII |
WGK Germany | WGK 3 |
Flash Point(F) | 91.4 °F |
Flash Point(C) | 33 °C |
Purity | ≥98.0% (GC) |
bp | 145-148 °C (lit.) |
Density | 0.815 g/mL at 20 °C (lit.); 0.815 g/mL at 20 °C |
Refractive Index | n |
UNSPSC | 12352001 |