Simvastatin
SIAL/38956 - analytical standard
CAS Number: 79902-63-9
Empirical Formula (Hill Notation): C25H38O5
Molecular Weight: 418.57
MDL Number: MFCD00072007
Linear Formula: C25H38O5
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 38956-10MG
| application(s) | forensics and toxicology pharmaceutical (small molecule) veterinary |
| assay | ≥98.0% (HPLC) |
| format | neat |
| grade | analytical standard |
| impurities | ≤0.5% water |
| InChI | 1S/C25H38O5/c1-6-25(4,5)2 |
| InChI key | RYMZZMVNJRMUDD-HGQWONQESA |
| mp | 127-132 °C (lit.) |
| optical activity | [α]/D +275±25°, c = 1 in acetonitrile |
| Quality Level | 100  |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | [H][C@]12[C@H](C[C@@H](C) |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| Biochem/physiol Actions: | Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147). |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361d |
| Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.0% (HPLC) |
| mp | 127-132 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |