2,5-Dihydroxybenzoic acid

SIAL/39319 - matrix substance for MALDI-MS, ≥99.5% (HPLC), Ultra pure

Synonym: 2,5-DHBA; DHB; Gentisic acid; Hydroquinonecarboxylic acid

CAS Number: 490-79-9
Empirical Formula (Hill Notation): C₇H₆O₄
Molecular Weight: 154.12
EC Number: 207-718-5
MDL Number: MFCD00002460
Linear Formula: (HO)₂C₆H₃CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-39319-10X10MG-F	10 mg	$346.00 10/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 39319-10MG-F

Properties
Descriptions
Safety Info.
Basic Data

analyte chemical class(es)	glycans, lipids, organic molecules, peptides, proteins
analyte functional class(es)	polymers
assay	≥99.5% (HPLC)
cation traces	Al: ≤1 mg/kg
	Ba: ≤1 mg/kg
	Ca: ≤1 mg/kg
	Cd: ≤1 mg/kg
	Co: ≤1 mg/kg
	Cr: ≤1 mg/kg
	Cu: ≤1 mg/kg
	Fe: ≤1 mg/kg
	K: ≤1 mg/kg
	Li: ≤1 mg/kg
	Mg: ≤1 mg/kg
	Mn: ≤1 mg/kg
	Na: ≤1 mg/kg
	Ni: ≤1 mg/kg
	Pb: ≤1 mg/kg
	Sr: ≤1 mg/kg
	Zn: ≤1 mg/kg
grade	matrix substance for MALDI-MS
InChI	1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)
InChI key	WXTMDXOMEHJXQO-UHFFFAOYSA-N
mp	203-207 °C
	204-208 °C (lit.)
Quality Level	100
SMILES string	OC(=O)c1cc(O)ccc1O
solubility	methanol: 10 mg/mL, clear
technique(s)	MALDI-MS: suitable

Application:

Quantitative MALDI-MS and Imaging of Fungicide Pyrimethanil in Strawberries with 2-Nitrophloroglucinol as an Effective Matrix.: This research highlights the application of 2,5-Dihydroxybenzoic acid (DHB) as an effective matrix for MALDI-MS imaging, providing enhanced detection sensitivity for fungicides in agricultural samples. The study showcases DHB’s role in improving the quantification and spatial resolution of pesticide residues within fruit matrices, demonstrating its utility in food safety and chemical analysis (Liang et al., 2024 ).

A maize enzyme from the 2-oxoglutarate-dependent oxygenase family with unique kinetic properties, mediates resistance against pathogens and regulates senescence.: Utilizing 2,5-Dihydroxybenzoic acid in enzyme kinetics studies, this paper reveals its critical role in modulating plant defense mechanisms against pathogens. The study provides insights into the biochemical pathways influenced by DHB, underscoring its importance in plant biochemistry and resistance breeding (Casati et al., 2024 ).

Unveiling the distribution of free and bound phenolic acids, flavonoids, anthocyanins, and proanthocyanidins in pigmented and non-pigmented rice genotypes.: This comprehensive analysis employs 2,5-Dihydroxybenzoic acid to investigate the phenolic content in different rice varieties, highlighting its role in enhancing the detection of health-beneficial compounds. The research supports DHB’s application in nutritional studies and crop quality assessments (Thulasinathan et al., 2024 ).

Novel Small Molecule Matrix Screening for Simultaneous MALDI Mass Spectrometry Imaging of Multiple Lipids and Phytohormones.: Leveraging the chemical properties of 2,5-Dihydroxybenzoic acid, this study introduces a novel matrix for MALDI-MS imaging, enhancing the simultaneous visualization of lipids and phytohormones in biological tissues. It highlights the versatility of DHB in facilitating complex biochemical analyses (Shi et al., 2024 ).

2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine as a Novel Matrix for Enhanced MALDI Imaging of Tissue Metabolites.: This research demonstrates the use of DHB-based matrices to improve the MALDI imaging of metabolites, offering greater sensitivity and specificity in clinical diagnostics and metabolic studies. The findings contribute to the broader application of DHB in analytical chemistry (Wang et al., 2024 ).

Packaging:

Bottomless glass bottle. Contents are inside inserted fused cone.

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥99.5% (HPLC)
mp	203-207 °C; 204-208 °C (lit.)
UNSPSC	41116105

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