α-Cyano-4-hydroxycinnamic acid
SIAL/39468 - matrix substance for MALDI-MS, Ultra pure
Synonym: α-CCA; α-CHCA; α-Cyano; 4-HCCA; ACCA
CAS Number: 28166-41-8
Empirical Formula (Hill Notation): C10H7NO3
Molecular Weight: 189.17
EC Number: 248-879-1
MDL Number: MFCD00004204
Linear Formula: HOC6H4CH=C(CN)CO2H
Product Type: Chemical
analyte chemical class(es) | glycans, peptides, proteins |
cation traces | Al: ≤1 mg/kg |
Ba: ≤1 mg/kg | |
Ca: ≤1 mg/kg | |
Cd: ≤1 mg/kg | |
Co: ≤1 mg/kg | |
Cr: ≤1 mg/kg | |
Cu: ≤1 mg/kg | |
Fe: ≤1 mg/kg | |
K: ≤1 mg/kg | |
Li: ≤1 mg/kg | |
Mg: ≤1 mg/kg | |
Mn: ≤1 mg/kg | |
Na: ≤1 mg/kg | |
Ni: ≤1 mg/kg | |
Pb: ≤1 mg/kg | |
Sr: ≤1 mg/kg | |
Zn: ≤1 mg/kg | |
form | solid |
grade | matrix substance for MALDI-MS |
InChI | 1S/C10H7NO3/c11-6-8(10(13 |
InChI key | AFVLVVWMAFSXCK-VMPITWQZSA |
mp | 245-250 °C |
245-250 °C (lit.) | |
Quality Level | 100 ![]() |
SMILES string | OC(=O)C(=Cc1ccc(O)cc1)C |
solubility | methanol: 10 mg/mL, clear |
storage temp. | 2-8°C |
technique(s) | MALDI-MS: suitable |
Application: | It was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF. |
General description: | α-Cyano-4-hydroxycinnamic acid (α-CHCA) functions as matrix and helps in facilitating ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 - H317 - H319 - H335 |
Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
mp | 245-250 °C (lit.); 245-250 °C |
Storage Temp. | 2-8°C |
UNSPSC | 41116105 |