Tetrahydrofuran
SIAL/401757 - anhydrous, ≥99.9%, inhibitor-free
Synonym: THF; Butylene oxide; Oxolane; Tetramethylene oxide
CAS Number: 109-99-9
Empirical Formula (Hill Notation): C4H8O
Molecular Weight: 72.11
EC Number: 203-726-8
MDL Number: MFCD00005356
Linear Formula: C4H8O
Product Type: Chemical
assay | ≥99.9% |
autoignition temp. | 610 °F |
bp | 65-67 °C (lit.) |
density | 0.889 g/mL at 25 °C (lit.) |
evapn. residue | <0.0005% |
expl. lim. | 1.8-11.8 % |
form | liquid |
grade | anhydrous |
impurities | ≤20 ppm peroxide (as H2O2) |
<0.002% water | |
<0.005% water (100 mL pkg) | |
InChI | 1S/C4H8O/c1-2-4-5-3-1/h1- |
InChI key | WYURNTSHIVDZCO-UHFFFAOYSA |
mp | −108 °C (lit.) |
pH | ~7 |
Quality Level | 200 ![]() |
refractive index | n |
SMILES string | C1CCOC1 |
solubility | H2O: soluble |
vapor density | 2.5 (vs air) |
vapor pressure | 114 mmHg ( 15 °C) |
143 mmHg ( 20 °C) |
Application: | Tetrahydrofuran was used as a solvent in the formation of diacetylinic polymers. It may be used in the following processes: • Formation of butyrolactone (BTL) by green oxidation method. • Aqueous THF solution to modify the polystyrene surface by swelling process. • As a solvent for lignin depolymerization to isolate phenolic monomer. |
General description: | Tetrahydrofuran (THF) is a saturated cyclic ether with a potential use as a biofuel. Its combustion studies have been investigated. Reports suggest that it is a better promoter than 1,3 dioxolane for CO2-hydrate formation. |
Legal Information: | Pure-Pac is a registered trademark of Sigma-Aldrich Co. LLC |
Other Notes: | "Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (673277) ![]() ![]() Read more about THF alternatives: 2-Methyltetrahydroun (2-MeTHF): A biomass-Derived solvent with Broad Applications in Organic Chemistry ![]() ![]() The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent ![]() ![]() |
Other Notes: | Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723. |
Packaging: | 1, 6×1, 2, 4×2 L in Sure/Seal™ |
Packaging: | 100, 12×100 mL in Sure/Seal™ |
Packaging: | 18 L in Pure-Pac™ 1 |
Packaging: | 20, 50 L in Pure-Pac™ 2 |
Packaging: | 200 L in Pure-Pac™ 2 |
Packaging: | 56 L in Pure-Pac™ 1 |
Packaging: | View returnable container options ![]() |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H225 - H302 - H319 - H335 - H336 - H351 |
Precautionary statements | P201 - P202 - P210 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | F,Xn |
Risk Statements | 11-19-36/37-40 |
Safety Statements | 13-16-29-33-36-37-46 |
RIDADR | UN 2056 3 / PGII |
WGK Germany | WGK 1 |
Flash Point(F) | -6.2 °F - closed cup |
Flash Point(C) | -21.2 °C - closed cup |
Supplemental Hazard Statements | EUH019 |
Purity | ≥99.9% |
bp | 65-67 °C (lit.) |
mp | −108 °C (lit.) |
Density | 0.889 g/mL at 25 °C (lit.) |
Refractive Index | n |
UNSPSC | 12191501 |