Super-DHB

SIAL/50862 - suitable for matrix substance for MALDI-MS, ≥99.0%

CAS Number: 63542-76-7
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-50862-10X10MG-F	10 mg	$292.00 10/EA	Add To Favorites
45-50862-1G-F	1 g	$104.00 1/EA	Add To Favorites
45-50862-5G-F	5 g	$398.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 50862-10MG-F

Properties
Descriptions
Safety Info.
Basic Data

analyte chemical class(es)	glycans, peptides, proteins
analyte functional class(es)	polymers
assay	≥99.0%
	≥99.0% (sum of DHB and 2-hydroxy-5-methoxybenzoic acid, HPLC)
cation traces	Ca: ≤5 mg/kg
	Cd: ≤5 mg/kg
	Co: ≤5 mg/kg
	Cr: ≤5 mg/kg
	Cu: ≤5 mg/kg
	Fe: ≤5 mg/kg
	K: ≤5 mg/kg
	Li: ≤5 mg/kg
	Mg: ≤5 mg/kg
	Mn: ≤5 mg/kg
	Na: ≤5 mg/kg
	Ni: ≤5 mg/kg
	Pb: ≤5 mg/kg
	Zn: ≤5 mg/kg
Quality Level	100
solubility	methanol: 1%, clear
suitability	suitable for matrix substance for MALDI-MS
technique(s)	MALDI-MS: suitable

Analysis Note:	9:1 mixture of DHB and 2-hydroxy-5-methoxybenzoic acid
General description:	The “super-DHB” matrix consists of a 9:1 (w/w) mixture of 2,5-DHB and 2-hydroxy-5-methoxybenzoic acid, respectively, since this ratio was found to be the most effective. The beneficial effect of the 2-hydroxy- 5-methoxybenzoic acid additive is attributed to a disorder in the 2,5-DHB crystal lattice resulting in enhanced ion desorption (i.e. ‘softer’ desorption) and reduced internal energy, which in turn results in reduced metastable fragmentation. An increase in sensitivity of up to 2 to 3-fold has been reported for a standard dextran mixture with concomitant enhanced resolution attributed to reduced metastable ion formation. The super-DHB matrix has also been reported to generate enhanced signals from tryptic glycopeptides. The use of super-DHB matrix is reported to reduce the presence of matrix background ions and result in glycan signals exhibiting better signal to noise ratios and higher resolution in the mass spectrum.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (sum of DHB and 2-hydroxy-5-methoxybenzoic acid, HPLC); ≥99.0%
UNSPSC	12000000

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