Hexamethyldisilazane
SIAL/52619 - for GC derivatization, LiChropur™, ≥99.0% (GC)
Synonym: HMDS
CAS Number: 999-97-3
Empirical Formula (Hill Notation): C6H19NSi2
Molecular Weight: 161.39
EC Number: 213-668-5
MDL Number: MFCD00008259
Linear Formula: (CH3)3SiNHSi(CH3)3
Product Type: Chemical
assay | ≥99.0% (GC) |
bp | 125 °C (lit.) |
form | liquid |
grade | for GC derivatization |
InChI | 1S/C6H19NSi2/c1-8(2,3)7-9 |
InChI key | FFUAGWLWBBFQJT-UHFFFAOYSA |
quality | LiChropur™ |
Quality Level | 100 ![]() |
reaction suitability | reagent type: derivatization reagent reaction type: Silylations |
refractive index | n |
n |
|
SMILES string | C[Si](C)(C)N[Si](C)(C)C |
technique(s) | gas chromatography (GC): suitable |
Application: | Learn more in the Product Information ![]() |
Application: | Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS). |
Application: | Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol |
Features and Benefits: | • HMDS is inexpensive and has a relatively low boiling point (124-127 °C). • It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts. • The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion. |
General description: | Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds. |
Legal Information: | LiChropur is a trademark of Merck KGaA, Darmstadt, Germany |
Other Notes: | Important silylating agent |
Other Notes: | Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes. |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H225 - H302 + H332 - H311 - H314 - H412 |
Precautionary statements | P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
Hazard Codes | F,C |
Risk Statements | 11-20/21/22-52/53 |
Safety Statements | 36/37-61 |
RIDADR | UN 1992 6.1(3) / PGII |
WGK Germany | WGK 2 |
Flash Point(F) | 52.5 °F - closed cup |
Flash Point(C) | 11.4 °C - closed cup |
Purity | ≥99.0% (GC) |
bp | 125 °C (lit.) |
Refractive Index | n |
UNSPSC | 12000000 |