Hexamethyldisilazane

SIAL/52619 - for GC derivatization, LiChropur^™, ≥99.0% (GC)

Synonym: HMDS

CAS Number: 999-97-3
Empirical Formula (Hill Notation): C₆H₁₉NSi₂
Molecular Weight: 161.39
EC Number: 213-668-5
MDL Number: MFCD00008259
Linear Formula: (CH₃)₃SiNHSi(CH₃)₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-52619-50ML	50 mL	$76.80 1/EA		Add To Favorites
45-52619-250ML	250 mL	$317.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0% (GC)
bp	125 °C (lit.)
form	liquid
grade	for GC derivatization
InChI	1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
InChI key	FFUAGWLWBBFQJT-UHFFFAOYSA-N
quality	LiChropur^™
Quality Level	100
reaction suitability	reagent type: derivatization reagent reaction type: Silylations
refractive index	n20/D 1.407 (lit.)
	n20/D 1.408
SMILES string	C[Si](C)(C)N[Si](C)(C)C
technique(s)	gas chromatography (GC): suitable

Application:	Learn more in the Product Information
Application:	Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds. It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).
Application:	Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.
Features and Benefits:	• HMDS is inexpensive and has a relatively low boiling point (124-127 °C). • It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts. • The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.
General description:	Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.
Legal Information:	LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	Important silylating agent
Other Notes:	Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Symbol	GHS02,GHS05,GHS06
Signal word	Danger
Hazard statements	H225 - H302 + H332 - H311 - H314 - H412
Precautionary statements	P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	F,C
Risk Statements	11-20/21/22-52/53
Safety Statements	36/37-61
RIDADR	UN 1992 6.1(3) / PGII
WGK Germany	WGK 2
Flash Point(F)	52.5 °F - closed cup
Flash Point(C)	11.4 °C - closed cup

Purity	≥99.0% (GC)
bp	125 °C (lit.)
Refractive Index	n20/D 1.407 (lit.); n20/D 1.408
UNSPSC	12000000

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