Polysorbate 80
SIAL/59924 - tested according to Ph. Eur.
Synonym: TWEEN® 80; Polysorbatum 80; POE (20) sorbitan monooleate; Polyethylene glycol sorbitan monooleate; Polyoxyethylenesorbitan monooleate; Polysorbate 80
CAS Number: 9005-65-6
MDL Number: MFCD00082107
Product Type: Chemical
| agency | tested according to Ph. Eur. |
| USP/NF | |
| aggregation number | 60 |
| application(s) | pharmaceutical (small molecule) |
| CMC | 0.012 |
| density | 1.064 g/mL at 25 °C (lit.) |
| description | non-ionic |
| form | liquid |
| HLB | 15 |
| InChI | 1S/C32H60O10/c1-2-3-4-5-6 |
| InChI key | RGPBUVUVZKQNHD-MDZDMXLPSA |
| mol wt | average mol wt 79,000 |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | CCCCCCCC/C=C/CCCCCCCC(=O) |
| transition temp | cloud point 65 °C |
| vapor pressure | <1 mmHg ( 20 °C) |
| Application: | Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy. |
| Biochem/physiol Actions: | Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration. |
| General description: | Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains. |
| Legal Information: | TWEEN is a registered trademark of Croda International PLC |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.064 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12161900 |