Losartan potassium

SIAL/61188

Synonym: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt; 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt; DuP 753; MK 954; Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide

CAS Number: 124750-99-8
Empirical Formula (Hill Notation): C₂₂H₂₂ClKN₆O
Molecular Weight: 461.00
MDL Number: MFCD02092704
Linear Formula: C₂₂H₂₂ClKN₆O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-61188-100MG	100 mg	$219.00 1/EA	Add To Favorites
45-61188-100MG-9	100 mg	No Price

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 61188-100MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	forensics and toxicology pharmaceutical (small molecule) veterinary
form	powder or crystals
impurities	≤0.5% water
InChI	1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChI key	OXCMYAYHXIHQOA-UHFFFAOYSA-N
Quality Level	200
shelf life	limited shelf life, expiry date on the label
SMILES string	CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following: • Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques. • Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.
Application:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions:	Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.
Biochem/physiol Actions:	orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist
General description:	Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.
General description:	Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.
Other Notes:	Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial .
Packaging:	100 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

41116107

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