Lectin from Triticum vulgaris
SIAL/61767 - lyophilized, ≥55% (GE), powder
Synonym: WGA; Wheat germ agglutinin
MDL Number: MFCD00147408
Product Type: Chemical
| biological source | Triticum vulgaris |
| concentration | ≥55% (GE) |
| form | powder |
| quality | lyophilized |
| storage temp. | 2-8°C |
| technique(s) | agglutination assay: suitable using fresh human erythrocytes |
| Application: | Lectin from Triticum vulgaris has been used in bone resorption assays. |
| Application: | Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles. |
| Biochem/physiol Actions: | Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism. |
| General description: | Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface. |
| General description: | WGA is not blood group specific but has an affinity for N-acetyl-β- |
| Other Notes: | Molecular characteristics and specificity for sugar binding |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |