α2-Macroglobulin from human plasma
SIAL/63013 - ≥90% (GE)
Synonym: α2-M
CAS Number: 1631137-21-7
MDL Number: MFCD00130472
Product Type: Chemical
α2-Macroglobulin is a tetramer with four identical subunits with molecular weights of 179 kDa. Upon binding to a protease, the 179 kDa subunit is cleaved into two 85 kDa fragments.
| assay | ≥90% (GE) |
| biological source | human plasma |
| mol wt | ~720 kDa (four glycoprotein subunits) |
| Quality Level | 100  |
| shipped in | wet ice |
| solubility | H2O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01023  |
| Analysis Note: | 100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0 |
| Analysis Note: | Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg. |
| Application: | Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. |
| Biochem/physiol Actions: | α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation. |
| Other Notes: | Conformational changes of α2-M |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (GE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |