(R)-(−)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride

SIAL/65363 - derivatization grade (chiral), LiChropur^™, ≥99.0%

Synonym: (R)-(−)-MTPA-Cl; Mosher’s acid chloride

CAS Number: 39637-99-5
Empirical Formula (Hill Notation): C₁₀H₈ClF₃O₂
Molecular Weight: 252.62
MDL Number: MFCD00044400
Linear Formula: C₆H₅C(OCH₃)(CF₃)COCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-65363-100MG	100 mg	$162.00 1/EA	Add To Favorites
45-65363-500MG	500 mg	$640.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 65363-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0%
	≥99.0% (AT)
bp	213-214 °C (lit.)
density	1.35 g/mL at 25 °C (lit.)
grade	derivatization grade (chiral)
InChI	1S/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1
InChI key	PAORVUMOXXAMPL-VIFPVBQESA-N
optical activity	[α]20/D −137±2°, c = 6.4% in carbon tetrachloride
optical purity	enantiomeric ratio: ≥99.5:0.5 (GC)
product line	ChiraSelect^™
quality	LiChropur^™
Quality Level	100
refractive index	n20/D 1.469
	n20/D 1.47 (lit.)
shipped in	wet ice
SMILES string	CO[C@](C(Cl)=O)(c1ccccc1)C(F)(F)F
storage temp.	−20°C
technique(s)	HPLC: suitable

Application:	It was used for derivatizing D-arabinitol and L-arabinitol samples for high performance thin layer chromatography (HPTLC) analysis for studying resolution of the diastereoisomer.
Application:	Ready-to-use reagent for the determination of the enantiomeric purity of alcohols and amines after derivatization; doi:10.1038/nprot.2007.354
General description:	(R)-(-)-a-Methoxy-a-(trifluoromethyl)phenylacetyl chloride (Mosher’s acid chloride) is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.
Legal Information:	ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
Legal Information:	LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	Discover LiChropur reagents ideal for HPLC or LC-MS analysis
Other Notes:	Please note that R(-)-MTPA-Cl is derived from S(-)-MTPA
Packaging:	100, 500 mg in glass bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 3265 8 / PGII
WGK Germany	WGK 3
Flash Point(F)	192.2 °F - closed cup
Flash Point(C)	89 °C - closed cup

Purity	≥99.0% (AT); ≥99.0%
bp	213-214 °C (lit.)
Density	1.35 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.469; n20/D 1.47 (lit.)
Storage Temp.	−20°C
UNSPSC	23151817

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