N-Methyl-bis(trifluoroacetamide)

SIAL/65943 - derivatization grade (GC derivatization), LiChropur^™, ≥99.0% (GC)

Synonym: MBTFA

CAS Number: 685-27-8
Empirical Formula (Hill Notation): C₅H₃F₆NO₂
Molecular Weight: 223.07
EC Number: 211-680-5
MDL Number: MFCD00000412
Linear Formula: CF₃CON(CH₃)COCF₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-65943-5ML	5 mL	$248.00 1/EA		Add To Favorites
45-65943-25ML	25 mL	$931.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0% (GC)
bp	121-122 °C (lit.)
density	1.547 g/mL at 25 °C
grade	derivatization grade (GC derivatization)
InChI	1S/C5H3F6NO2/c1-12(2(13)4(6,7)8)3(14)5(9,10)11/h1H3
InChI key	AWGBWLXGUPTXHF-UHFFFAOYSA-N
quality	LiChropur^™
Quality Level	100
reaction suitability	reagent type: derivatization reagent reaction type: Acylations
	reagent type: derivatization reagent reaction type: Silylations
refractive index	n20/D 1.346
	n20/D 1.346 (lit.)
SMILES string	CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F
technique(s)	gas chromatography (GC): suitable

Application:	N-Methyl-bis(trifluoroacetamide) may be used as an on-column derivatization agent for the determination of amphetamine-type stimulants in biological samples, and ketamine, norketamine, dehydronorketamine in urine samples using gas chromatography coupled to mass spectrometry technique. It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions. Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B₆ vitamers), and thiols.
Application:	Reagent for introducing trifluoroacetyl group.
General description:	N-Methyl-bis(trifluoroacetamide) is a common reagent used in the alkylation process, which targets highly polar, multi-functional compounds such as carbohydrates and amino acids.
Legal Information:	LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	Reagent for trifluoroacetyl, N-trimethylsilyl-N-tifluoroacetyl and trimethylsilyl.
Other Notes:	Reagent for trifluoroacetylations under mild conditions

Symbol	GHS02,GHS05
Signal word	Danger
Hazard statements	H226 - H314
Precautionary statements	P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
Hazard Codes	C
Risk Statements	10-34
Safety Statements	26-36/37/39-45
RIDADR	UN 2920 3(8) / PGII
WGK Germany	WGK 3
Flash Point(F)	113.0 °F - closed cup
Flash Point(C)	45 °C - closed cup

Purity	≥99.0% (GC)
bp	121-122 °C (lit.)
Density	1.547 g/mL at 25 °C
Refractive Index	n20/D 1.346 (lit.); n20/D 1.346
UNSPSC	23151817

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