Acetonitrile

SIAL/675415 - HPLC Plus, ≥99.9%, poly-coated bottles

Synonym: ACN; Cyanomethane; Ethyl nitrile; Methyl cyanide

CAS Number: 75-05-8
Empirical Formula (Hill Notation): C₂H₃N
Molecular Weight: 41.05
EC Number: 200-835-2
MDL Number: MFCD00001878
Linear Formula: CH₃CN
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-675415-4L	4 L	$575.00 1/EA	Add To Favorites
45-675415-4X4L	4 L	$2350.00 4/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

absorption	≤1 mAU at 210 nm
application(s)	food and beverages
assay	≥99.9%
autoignition temp.	525 °F
	973 °F
bp	81-82 °C (lit.)
color	colorless
density	0.786 g/mL at 25 °C (lit.)
evapn. residue	≤0.0002%
expl. lim.	16 %
form	liquid
format	neat
grade	HPLC Plus
impurities	≤0.01% water
InChI	1S/C2H3N/c1-2-3/h1H3
InChI key	WEVYAHXRMPXWCK-UHFFFAOYSA-N
mp	−45 °C (lit.)
Quality Level	100
refractive index	n20/D 1.344 (lit.)
SMILES string	CC#N
solubility	water: soluble
technique(s)	HPLC: suitable
UV absorption	λ: 195 nm A_max: ≤0.10
	λ: 200 nm A_max: ≤0.02
	λ: 228 nm A_max: ≤0.005
vapor density	1.41 (vs air)
vapor pressure	72.8 mmHg ( 20 °C)

Application:	Anthocyanin Separation: Acetonitrile is employed in high-performance liquid chromatography (HPLC) for the selective separation of anthocyanins. Studies have demonstrated the benefits of replacing acetonitrile with methanol in the mobile phase to control the selectivity and improve the resolution of anthocyanin separation, providing a more sustainable approach to chromatographic analysis (Deineka et al., Journal of Analytical Chemistry, 2021 ). Detection of α-Amino Acids: Acetonitrile is used in the development of chemiluminescence methods for detecting α-amino acids. A mixed solution of water, acetonitrile, and ethyl acetate has been shown to enhance the sensitivity and accuracy of amino acid detection, making it a valuable tool for biochemical and clinical analyses (Kan et al., American Journal of Analytical Chemistry, 2020 ). Electrochemical Detection of Biomarkers: Acetonitrile is utilized in the electrochemical detection of biomarkers such as 5-formyluracil. Labeling with (2-benzimidazolyl) acetonitrile enhances the selectivity and sensitivity of the detection, making it an important method for biomedical research and diagnostics (Tang et al., Analytical Chemistry, 2021 ). Ligand-Assisted Excitation of Europium Complexes: Acetonitrile is used in studying the ligand-assisted excitation of Eu(III) complexes. The interaction of europium complexes with xenon difluoride in acetonitrile solution provides insights into their photophysical properties, which are essential for developing luminescent materials for various applications, including lighting and display technologies (Masyagutova et al., Journal of Fluorine Chemistry, 2024 ).
General description:	Acetonitrile (MeCN), an aliphatic nitrile, is a colorless liquid with a pleasant odor. It is widely used as a solvent and intermediate in organic syntheses. It is transparent to UV-visible light making it highly applicable in spectrophotometric and fluorimetric techniques. As MeCN has low viscosity, high elution strength and is highly miscible in water, it is utilized as a mobile phase component in many chromatographic techniques. Its infrared spectrum has been recorded. Synthesis of alkyl hydroperoxides in MeCN by alkane oxidation with hydrogen peroxide in the presence of iron complexes has been studied. The hydrogenation of MeCN to form ethylamine using Co–B amorphous alloy catalyst has been investigated.
Packaging:	4, 4×4 L in PVC-coated bottle

Symbol	GHS02,GHS07
Signal word	Danger
Hazard statements	H225 - H302 + H312 + H332 - H319
Precautionary statements	P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
Hazard Codes	F,Xn
Risk Statements	11-20/21/22-36
Safety Statements	16-36/37
RIDADR	UN 1648 3 / PGII
WGK Germany	WGK 2
Flash Point(F)	35.6 °F - closed cup
Flash Point(C)	2.0 °C - closed cup

Purity	≥99.9%
bp	81-82 °C (lit.)
mp	−45 °C (lit.)
Density	0.786 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.344 (lit.)
UNSPSC	12190000

To Order From a Quote