Nicotinamide
SIAL/72345 - ≥98.5% (HPLC)
Synonym: Niacinamide; Nicotinic acid amide; Pyridine-
CAS Number: 98-92-0
Empirical Formula (Hill Notation): C6H6N2O
Molecular Weight: 122.12
EC Number: 202-713-4
MDL Number: MFCD00006395
Linear Formula: C6H6N2O
Product Type: Chemical
| assay | ≥98.5% (HPLC) |
| biological source | synthetic |
| color | colorless to white |
| form | powder |
| InChI | 1S/C6H6N2O/c7-6(9)5-2-1-3 |
| InChI key | DFPAKSUCGFBDDF-UHFFFAOYSA |
| mp | 128-131 °C |
| 128-131 °C (lit.) | |
| Quality Level | 200  |
| SMILES string | NC(=O)c1cccnc1 |
| Application: | Nicotinamide has been used: • as a precursor to study its effect on nicotinamide adenine dinucleotide (NAD) concentration in NAD-deficient mammalian mitochondria • as an inhibitor of sirtuin (SIRT) family of deacetylases in in vitro serine hydroxymethyltransferase 2 (SHMT2) deacetylation assay • to study its effect on ischemia-reperfusion (I-R) injury-induced cell death in ptenαm/m mice |
| Biochem/physiol Actions: | Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor |
| Biochem/physiol Actions: | Nicotinamide serves as a precursor for β-nicotinamide adenine dinucleotide (NAD+) coenzyme production. It is involved in the synthesis of NAD+ phosphate (NADP+). It also regulates the mechanism of cell survival and cell death. Fatigue, skin pigmentation, decreased appetite and mouth ulcers are indications of nicotinamide deficiency. Its chronic deficiency can lead to pellagra. Nicotinamide is known to show protective effects on oxidative stress. |
| General description: | Nicotinamide is synthesized in the liver from nicotinic acid. It is also produced as a result of nicotinamide adenine dinucleotide (NAD+) hydrolysis. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 359.6 °F |
| Flash Point(C) | 182 °C |
| Purity | ≥98.5% (HPLC) |
| mp | 128-131 °C (lit.); 128-131 °C |
| UNSPSC | 12352200 |