3,3′-Diindolylmethane
SIAL/74601 - analytical standard
Synonym: 3,3′-Bisindolylmethane; DIM
CAS Number: 1968-05-4
Empirical Formula (Hill Notation): C17H14N2
Molecular Weight: 246.31
MDL Number: MFCD00195766
Linear Formula: C17H14N2
Product Type: Chemical
| application(s) | food and beverages |
| assay | ≥97.5% (HPLC) |
| format | neat |
| grade | analytical standard |
| InChI | 1S/C17H14N2/c1-3-7-16-14( |
| InChI key | VFTRKSBEFQDZKX-UHFFFAOYSA |
| Quality Level | 100  |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | C(c1c[nH]c2ccccc12)c3c[nH |
| storage temp. | 2-8°C |
| Application: | 3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells. |
| Biochem/physiol Actions: | Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system. |
| General description: | 3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 - H413 |
| Precautionary statements | P273 - P302 + P352 - P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.5% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |