3,3′-Diindolylmethane
SIAL/74601 - analytical standard
Synonym: 3,3′-Bisindolylmethane; DIM
CAS Number: 1968-05-4
Empirical Formula (Hill Notation): C17H14N2
Molecular Weight: 246.31
MDL Number: MFCD00195766
Linear Formula: C17H14N2
Product Type: Chemical
| application(s) | food and beverages |
| assay | ≥97.5% (HPLC) |
| format | neat |
| grade | analytical standard |
| InChI | 1S/C17H14N2/c1-3-7-16-14( |
| InChI key | VFTRKSBEFQDZKX-UHFFFAOYSA |
| Quality Level | 100  |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | C(c1c[nH]c2ccccc12)c3c[nH |
| storage temp. | 2-8°C |
| Application: | 3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells. |
| Biochem/physiol Actions: | Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system. |
| General description: | 3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 - H413 |
| Precautionary statements | P273 - P302 + P352 - P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.5% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |