Withanolide A

SIAL/74776 - analytical standard

Synonym: (5α,6α,7α,22R)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone; Withaniol

CAS Number: 32911-62-9
Empirical Formula (Hill Notation): C₂₈H₃₈O₆
Molecular Weight: 470.60
MDL Number: MFCD07779143
Linear Formula: C₂₈H₃₈O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-74776-10MG	10 mg	$855.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	food and beverages
assay	≥95.0% (HPLC)
format	neat
grade	analytical standard
InChI	1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1
InChI key	DXWHOKCXBGLTMQ-SFQAJKIESA-N
Quality Level	100
shelf life	limited shelf life, expiry date on the label
SMILES string	CC1=C(C)C(=O)O[C@H](C1)[C@](C)(O)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@]23C)[C@@]5(C)C(=O)C=CC[C@]5(O)[C@H]6O[C@@H]46
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Application:	Withanolide A may be used as an analytical standard for the determination of withanolide A in: • Mentat tablet, an Indian herbal medicine by UHPLC coupled to tandem mass spectrometry (MS/MS) operating with ESI, along with multivariate analysis. • Withania somnifera by ultra-high performance liquid chromatography-hybrid triple quadrupole linear ion trap mass spectrometer (UHPLC-QqQ LIT-MS) equipped with electrospray ionization (ESI) source and MRM detection, along with multivariate analysis as well as HPLC combined with diode array detector (DAD). • Withania coagulans by LC-QqQ-ESI-MS/MS.
Biochem/physiol Actions:	C₂₈-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer’s and Parkinson’s disease. In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.
General description:	Withanolide A is classified under the steroidal lactone group of bioactive compounds that are majorly found in Withania somnifera (L.).
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95.0% (HPLC)
UNSPSC	85151701

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