Pefabloc^® SC

SIAL/76307 - analytical standard

Synonym: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF

CAS Number: 30827-99-7
Empirical Formula (Hill Notation): C₈H₁₀FNO₂S · HCl
Molecular Weight: 239.69
MDL Number: MFCD00132962
Linear Formula: C₈H₁₀FNO₂S · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-76307-100MG	100 mg	$137.00 1/EA	Add To Favorites
45-76307-500MG	500 mg	$519.00 1/EA	Add To Favorites
45-76307-1G	1 g	$902.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	forensics and toxicology pharmaceutical (small molecule)
assay	≥95.0% (HPLC)
form	powder or crystals
format	neat
grade	analytical standard
InChI	1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI key	WRDABNWSWOHGMS-UHFFFAOYSA-N
Quality Level	200
shelf life	5 yr
SMILES string	FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	Pefabloc^® SC may be used as an analytical standard in determining the native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. It may also be used as an esterase inhibitor, which is added to the whole blood to improve the stability of ciclesonide for the determination of ciclesonide (CIC) and its active metabolite, desisobutyryl-ciclesonide (des-CIC), in human plasma using liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric (LC-APCI-MS/MS) method.
Application:	Recommended concentrations for use are 0.1-1 mM.
Application:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions:	4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) is an irreversible serine protease inhibitor. Inhibition constants are similar to those of phenylmethanesulfonyl fluoride (PMSF) and diisopropylfluorophosphate (DFP). AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein, and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water, and improved stability in aqueous solutions. AEBSF can be used in cell culture in concentrations of up to 0.25 mM.
General description:	Pefabloc^® SC is a potent, nontoxic and relatively easy to use, irreversible serine proteinase inhibitor. It is reported to efficiently inhibit the platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase) in both humans and rats.
General description:	Pefabloc^® SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.
Legal Information:	Pefabloc is a registered trademark of Pentapharm
Other Notes:	Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic; Unaffected by albumin

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319
Precautionary statements	P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95.0% (HPLC)
Storage Temp.	2-8°C
UNSPSC	41116107

To Order From a Quote