Temozolomide

SIAL/76899 - VETRANAL^®, analytical standard

Synonym: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide; 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; NSC 362856

CAS Number: 85622-93-1
Empirical Formula (Hill Notation): C₆H₆N₆O₂
Molecular Weight: 194.15
MDL Number: MFCD00866492
Linear Formula: C₆H₆N₆O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-76899-10MG	10 mg	$235.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	forensics and toxicology pharmaceutical (small molecule) veterinary
assay	≥99.0% (HPLC)
format	neat
grade	analytical standard
ign. residue	≤0.2%
InChI	1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key	BPEGJWRSRHCHSN-UHFFFAOYSA-N
loss	≤0.5% loss on drying
product line	VETRANAL^®
Quality Level	100
shelf life	limited shelf life, expiry date on the label
SMILES string	CN1N=Nc2c(ncn2C1=O)C(N)=O
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Application:	TMZ may be used as a reference standard for the analysis of temozolomide in serum and brain tumor samples by micellar electrokinetic capillary chromatography (MEKC), in aqueous solutions by liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS/MS), in active pharmaceutical ingredients (APIs) by high performance liquid chromatography (HPLC) with MS/MS and in pharmaceutical dosage form by HPLC equipped with photodiode array (PDA) detector.
General description:	Temozolomide (TMZ) is an alkylating agent of the imidazotetrazine derivatives that shows broad-spectrum antitumor activity against murine tumors.
Legal Information:	VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H315 - H319 - H335 - H340 - H350 - H360FD
Precautionary statements	P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Codes	T
Risk Statements	45-46-60-61-22-36/37/38
Safety Statements	53-26-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥99.0% (HPLC)
Storage Temp.	2-8°C
UNSPSC	41116107

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