Curcumin

SIAL/78246 - matrix substance for MALDI-MS, ≥99.5% (HPLC)

Synonym: (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Diferuloylmethane; Diferulylmethane; Natural Yellow 3

CAS Number: 458-37-7
Empirical Formula (Hill Notation): C₂₁H₂₀O₆
Molecular Weight: 368.38
EC Number: 207-280-5
MDL Number: MFCD00008365
Linear Formula: [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-78246-100MG	100 mg	$294.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.5% (HPLC)
cation traces	Na: ≤50 mg/kg
form	powder
grade	matrix substance for MALDI-MS
InChI	1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChI key	VFLDPWHFBUODDF-FCXRPNKRSA-N
mp	183-188 °C
Quality Level	100
SMILES string	COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O
storage temp.	2-8°C
technique(s)	MALDI-MS: suitable
vapor density	13 (vs air)

Application:

Hybrid Ethylcellulose Polymeric Films: Ag(I)-Based Components and Curcumin as Reinforcing Ingredients for Enhanced Food Packaging Properties: This research discusses the development of hybrid ethylcellulose films integrating curcumin to improve food packaging, emphasizing the analytical chemistry aspects like ingredient compatibility and performance evaluation (Crispini A et al., 2024 ).

Intelligent double-layer film based on gellan gum/modified anthocyanin/curcumin/sodium alginate/zinc oxide for monitoring shrimp freshness: This article describes the creation of an intelligent film incorporating curcumin for real-time monitoring of shrimp freshness, showcasing a practical application of curcumin in food safety and shelf-life extension (Li C et al., 2024 ).

Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery: This study examines a curcumin-incorporated cyclodextrin hydrogel, highlighting the use of curcumin in developing advanced drug delivery systems with potential applications in targeted therapy (Xu X et al., 2024 ).

Biochem/physiol Actions:

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.5% (HPLC)
mp	183-188 °C
Storage Temp.	2-8°C
Colour Index Number	75300
UNSPSC	12000000

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