Advanced Search



N-tert-Butyl-α-phenylnitrone

SIAL/80126 - for ESR-spectroscopy

Synonym: N-Benzylidene-tert-butylamine N-oxide; PBN; Phenyl N-t-butylnitrone

CAS Number: 3376-24-7
Empirical Formula (Hill Notation): C11H15NO
Molecular Weight: 177.24
EC Number: 222-168-6
MDL Number: MFCD00008799
Linear Formula: C6H5CH=N(O)C(CH3)3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-80126-1G 1 g
 $281.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 80126-1G

 

assay ≥99.5% (HPLC)
form powder
grade for ESR-spectroscopy
InChI 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChI key IYSYLWYGCWTJSG-XFXZXTDPSA-N
mp 72-74 °C
  73-74 °C (lit.)
Quality Level 100 
SMILES string CC(C)(C)[N+]([O-])=Cc1ccccc1
solubility chloroform: 50 mg/mL, clear, colorless
storage temp. −20°C
Application: N-tert-Butyl-a-phenylnitrone was used as spin trapping agent during measurement of scavenging rate constant of carotenoid using EPR spin-trapping technique. This reagent helps in obtaining a six-line ESR spectrum and hyperfine coupling constants, confirming the presence of carbon-based radical in uric acid and peroxynitrite, using electron spin resonance spectroscopy and liquid chromatography mass spectrometry.
Biochem/physiol Actions: N-tert-butyl-α-phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy. The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100Å g).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99.5% (HPLC)
mp 72-74 °C; 73-74 °C (lit.)
Storage Temp. −20°C
UNSPSC 12000000

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top