Streptomycin solution

SIAL/85886 - ~1 mg/mL in 1 mM EDTA, analytical standard

CAS Number: 3810-74-0
Empirical Formula (Hill Notation): C₂₁H₃₉N₇O₁₂ · 1.5H₂SO₄
Molecular Weight: 728.69
MDL Number: MFCD00037023
Linear Formula: C₂₁H₃₉N₇O₁₂ · 1.5H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-85886-10ML	10 mL	$96.50 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
application(s)	pharmaceutical (small molecule)
color	colorless
concentration	~1 mg/mL in 1 mM EDTA
form	liquid
format	single component solution
grade	analytical standard
InChI	1S/2C21H39N7O12.3H2O4S/c21-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;31-5(2,3)4/h24-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
InChI key	QTENRWWVYAAPBI-YZTFXSNBSA-N
mode of action	protein synthesis \| interferes
Quality Level	100
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:	Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Application:	Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Application:	Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).
Biochem/physiol Actions:	Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation. Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin. Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Packaging:	10ml
Preparation Note:	This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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