Hydrogen chloride - 1-butanol solution

SIAL/87472 - ~3 M in 1-butanol, for GC derivatization, LiChropur^™

CAS Number: 7647-01-0
MDL Number: MFCD00011324
Product Type: Chemical

concentration	~3 M in 1-butanol
density	0.87 g/mL at 20 °C
form	solution
grade	for GC derivatization
InChI	1S/ClH/h1H
InChI key	VEXZGXHMUGYJMC-UHFFFAOYSA-N
quality	LiChropur^™
Quality Level	100
reaction suitability	reagent type: derivatization reagent reaction type: Acylations
SMILES string	Cl
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable

Application:	Hydrogen chloride - 1-butanol solution has been used for butylation of amino acids during blood sample analysis for determination of ethylenediaminetetraacetic acid using mass spectrometry.
General description:	Acylation, an alternative to silylation, is the conversion of compounds that contain active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides through the action of a carboxylic acid or derivative. The presence of a carbonyl group adjacent to the halogenated carbons enhances electron capture detector (ECD) response. Acylation has many benefits: • It improves the stability of compounds by protecting unstable groups. • It may confer volatility on substances such as carbohydrates or amino acids, which have so many polar groups that they are non-volatile and normally decompose on heating. • It assists in separations not possible with underivatized compounds. • Compounds are detectable at very low levels with an ECD. Hydrogen chloride-1-butanol is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
Legal Information:	LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	Reagent for the esterification of amino acids and carnites for GC-MS analysis