Mycophenolic acid
SIAL/89287 - analytical standard
Synonym: 6-
CAS Number: 24280-93-1
Empirical Formula (Hill Notation): C17H20O6
Molecular Weight: 320.34
EC Number: 246-119-3
MDL Number: MFCD00036814
Linear Formula: C17H20O6
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 89287-10MG
| application(s) | forensics and toxicology pharmaceutical (small molecule) |
| assay | ≥98.5% (HPLC) |
| format | neat |
| grade | analytical standard |
| impurities | ≤1.0% water |
| InChI | 1S/C17H20O6/c1-9(5-7-13(1 |
| InChI key | HPNSFSBZBAHARI-RUDMXATFSA |
| Quality Level | 100  |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | COc1c(C)c2COC(=O)c2c(O)c1 |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL. |
| Application: | Mycophenolic acid may be used as a reference standard for the determination of the analyte in human plasma by ultra-performance liquid chromatography tandem mass spectrometry. |
| Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| Biochem/physiol Actions: | Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase. |
| Caution: | As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly. |
| General description: | Mycophenolic acid is an active metabolite of the ester prodrug mycophenolate mofetil (MPM), which is prescribed as an immunosuppressant to prevent the organ transplantation rejection and also in the treatment of certain autoimmune diseases. |
| Preparation Note: | Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C. |
| Symbol |    GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H302 - H341 - H360D - H372 - H410 |
| Precautionary statements | P201 - P273 - P301 + P312 + P330 - P308 + P313 |
| Hazard Codes | T,N |
| Risk Statements | 61-22-48/25-50/53-68 |
| Safety Statements | 53-22-45-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.5% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |