White-Clark catalyst
SIAL/901425
Synonym: [MnIII(ClPc)]Cl
CAS Number: 2226663-68-7
Empirical Formula (Hill Notation): C32Cl17MnN8
Molecular Weight: 1154.04
Linear Formula: C32Cl17MnN8
Product Type: Custom product
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901425-100MG.
| form | powder |
| reaction suitability | reagent type: catalyst core: manganese |
| Application: | This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF4) or Lewis acid (BF3), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens. |
| Legal Information: | This product is patent pending under application #62/569,872. |
| Other Notes: | Manganese-catalysed benzylic C(sp3)–H amination for late-stage functionalization   |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352300 |