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Retigabine

SIAL/90221 - analytical standard

Synonym: D-23129; Ezogabine; N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

CAS Number: 150812-12-7
Empirical Formula (Hill Notation): C16H18FN3O2
Molecular Weight: 303.33
MDL Number: MFCD04307735
Linear Formula: C16H18FN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-90221-25MG 25 mg
 $176.00
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application(s) forensics and toxicology
veterinary
assay ≥98.0% (HPLC)
drug control USDEA Schedule IV
format neat
grade analytical standard
impurities ≤1.0% water (calc. from elemental analysis)
InChI 1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
InChI key PCOBBVZJEWWZFR-UHFFFAOYSA-N
Quality Level 100 
shelf life limited shelf life, expiry date on the label
SMILES string FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1
storage temp. 2-8°C
technique(s) gas chromatography (GC): suitable
  HPLC: suitable
Application: Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).
Biochem/physiol Actions: Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.
Biochem/physiol Actions: Retigabine is a Kv7.2-7.5 potassium channel activator; anticonvulsant.
General description: Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.
Purity ≥98.0% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41116107

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