Acetic anhydride
SIAL/91204 - derivatization grade (GC derivatization), LiChropur™, ≥99.0%
CAS Number: 108-24-7
Empirical Formula (Hill Notation): C4H6O3
Molecular Weight: 102.09
EC Number: 203-564-8
MDL Number: MFCD00008705
Linear Formula: (CH3CO)2O
Product Type: Chemical
| assay | ≥99.0% |
| ≥99.0% (GC) | |
| autoignition temp. | 629 °F |
| bp | 138-140 °C (lit.) |
| density | 1.08 g/mL (lit.) |
| evapn. residue | ≤0.003% |
| expl. lim. | 10.3 % |
| form | liquid |
| grade | derivatization grade (GC derivatization) |
| InChI | 1S/C4H6O3/c1-3(5)7-4(2)6/ |
| InChI key | WFDIJRYMOXRFFG-UHFFFAOYSA |
| mp | −73 °C (lit.) |
| quality | LiChropur™ |
| Quality Level | 100  |
| reaction suitability | reagent type: derivatization reagent reaction type: Acylations |
| refractive index | n |
| SMILES string | CC(=O)OC(C)=O |
| solubility | H2O: slightly soluble |
| technique(s) | gas chromatography (GC): suitable |
| vapor density | 3.5 (vs air) |
| vapor pressure | 10 mmHg ( 36 °C) |
| 4 mmHg ( 20 °C) |
| Application: | Learn more in the Product Information |
| Application: | Suitable for the derivatization of acetyl, acetaminophen, alcohols, aldoses and partially methylated aldoses, aldosterone, amines, amino acids, amino sugars (in polysaccharides), amino sugar methyl glycosides, 2-amino-2-deoxyhexoses, arginyl peptides, aryl sulfate esters, bile acids, carbamates, carbohydrates, cerebrosides, cystine and cysteine (in peptides), desmethyldoxepin, 3,4-dihydroxyphenylglycol |
| General description: | Acetic anhydride is an esterification agent which is corrosive to metals. It is a colourless liquid with strong vinegar-like odour. It is mostly used in making plastics, fibers, pharmaceuticals, dyes and explosives. |
| General description: | Acylation, an alternative to silylation, enables the conversion of compounds that comprise of active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides by the action of a carboxylic acid or derivative. The carbonyl group adjacent to the halogenated carbons favors the improvement of electron capture detector (ECD) response. Acylation has several benefits: • It increases the stability of compounds by protecting unstable groups. • It may render volatility on substances like carbohydrates or amino acids, that have several polar groups that they are non-volatile and generally decompose on heating. • It allows the separations not possible with underivatized compounds. • Compounds are detectable at very low levels with an ECD. Acetic anhydride is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis. |
| Legal Information: | LiChropur is a trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Reagent for acetic anhydride, acetyl, n-acetyl, n-acetyl-n, o-acetyl, acetate, aldononitrile acetate, aminoglycitol acetate, aryl acetate, permethyl acetyl, methyl ester, trifluoroacetyl, bis-trimethylsilyl, trimethylsilyl polyamino alcohol, and O-trimethylsilyl (TMS). |
| Packaging: | 10×1 mL in glass insert |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H226 - H302 - H314 - H330 |
| Precautionary statements | P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 10-20/22-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1715 3(8) / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 120.2 °F - closed cup |
| Flash Point(C) | 49 °C - closed cup |
| Supplemental Hazard Statements | EUH071 |
| Purity | ≥99.0% (GC); ≥99.0% |
| bp | 138-140 °C (lit.) |
| mp | −73 °C (lit.) |
| Density | 1.08 g/mL (lit.) |
| Refractive Index | n |
| UNSPSC | 41115710 |