Trichloroacetic acid
SIAL/91230 - ACS reagent, for the determination of Fe in blood according to Heilmeyer, ≥99.5%
Synonym: TCA
CAS Number: 76-03-9
Empirical Formula (Hill Notation): C2HCl3O2
Molecular Weight: 163.39
EC Number: 200-927-2
MDL Number: MFCD00004177
Linear Formula: Cl3CCOOH
Product Type: Chemical
| anion traces | chloride (Cl-): ≤10 mg/kg |
| nitrate (NO3-): ≤20 mg/kg | |
| phosphate (PO43-): ≤5 mg/kg | |
| sulfate (SO42-): ≤200 mg/kg | |
| assay | ≥99.5% |
| ≥99.5% (T) | |
| bp | 196 °C (lit.) |
| cation traces | Ca: ≤10 mg/kg |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤50 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| density | 1.62 g/mL at 25 °C (lit.) |
| form | flakes |
| functional group | carboxylic acid |
| chloro | |
| grade | ACS reagent |
| ign. residue | ≤0.03% (as SO4) |
| InChI | 1S/C2HCl3O2/c3-2(4,5)1(6) |
| InChI key | YNJBWRMUSHSURL-UHFFFAOYSA |
| mp | 54-58 °C (lit.) |
| quality | for the determination of Fe in blood according to Heilmeyer |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | OC(=O)C(Cl)(Cl)Cl |
| solubility | water: soluble 81.7 g/L at 20 °C |
| vapor density | <1 (vs air) |
| vapor pressure | 1 mmHg ( 51 °C) |
| Application: | Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy. |
| Application: | Trichloroacetic acid may be used in the following studies: • Estimation of phosphorus in various biological samples (serum, urine and stool ash solutions). • Elimination of acid-soluble and lipid phosphorous during the determination of deoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues. • Preparation of 2-methyl-4-nitroanilinium trichloroacetate trichloroacetic acid (2M4NATCA) crystals. 10% Trichloroacetic acid may be employed for the preparation of radioactive proteins. |
| General description: | Trichloroacetic acid (TCA) is a chlorinated acetic acid. It is one of the major metabolites of trichloroethylene (TCE). |
| Other Notes: | Protein denaturant. |
| Symbol |    GHS05,GHS07,GHS09 |
| Signal word | Danger |
| Hazard statements | H314 - H335 - H410 |
| Precautionary statements | P260 - P271 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338 |
| Hazard Codes | C,N |
| Risk Statements | 35-50/53 |
| Safety Statements | 26-36/37/39-45-60-61 |
| RIDADR | UN 1839 8 / PGII |
| WGK Germany | WGK 2 |
| Flash Point(F) | > 235.4 °F - closed cup |
| Flash Point(C) | > 113 °C - closed cup |
| Purity | ≥99.5% (T); ≥99.5% |
| bp | 196 °C (lit.) |
| mp | 54-58 °C (lit.) |
| Density | 1.62 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352100 |