Cyrene™ 2-Methyltetrahydrofuran Blend
SIAL/920193 - BioRenewable
Synonym: 2-MeTHF Solution; 2-
Empirical Formula (Hill Notation): C6H8O3
Molecular Weight: 128.13
Linear Formula: C6H8O3
Product Type: Chemical
Similar physical properties of NMP and DMF while maintaining high reaction yields
Cyrene™ and Cyrene™ Blends have been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions
Similar physical properties of NMP and DMF while maintaining high reaction yields
Cyrene™ and Cyrene™ Blends have been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions
12 Principles of Green Chemistry: Principle 5—Safer Solvents and Auxiliaries. This product utilizes reduced volumes of auxiliary substances that are less hazardous.
12 Principles of Green Chemistry: Principle 7—A raw material or feedstock should be renewable rather than depleting whenever technically and economically practicable.
| contains | 30-80 ppm BHT as stabilizer |
| density | 1.153 g/mL |
| form | liquid |
| greener alternative category | Aligned  |
| greener alternative product characteristics | Safer Solvents and Auxiliaries Use of Renewable Feedstocks Learn more about the Principles of Green Chemistry . |
| renewable carbon content | 100% |
| Application: | This cosolvent solution has been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions, such as: • HATU Amide Coupling - Replacement for DMF in amide and dipeptide coupling reactions • Suzuki-Miyaura coupling reaction • Sonogashira coupling reaction |
| Features and Benefits: | • Independently certified as 100% renewable carbon. • Closer physical properties of NMP and DMF while maintaining high reaction yields. • Sustainably produced and environmentally less hazardous than more traditional petroleum aprotic solvents • Both Cyrene • It has a lower viscosity than neat Cyrene |
| General description: | Cyrene™ 2-Methyltetrahydrofuran Blend with BHT as an inhibitor is specially formulated for use in automated processes and applications where lower viscosity is required, making it easier to handle while maintaining high yields. This Cyrene™ blend is an alternative for NMP and DMF in many cross-coupling reactions. Neither Cyrene™ nor 2-Methyltetrahydrofuran have any genotoxic or mutagenic concerns associated with their use, making them much safer alternatives to traditional aprotic solvents. This new blend is part of our Biorenewable product line, meaning that it is made from renewable resources and does not compete with food resources for its production, making it more environmentally sustainable for the future. The material has also been independently certified as 100% renewable carbon. |
| Legal Information: | CYRENE is a trademark of Circa Group Pvt Ltd |
| Other Notes: | To see other BioRenewable or Greener Solvents |
| Symbol |   GHS02,GHS05 |
| Signal word | Danger |
| Hazard statements | H225 - H315 - H318 |
| Precautionary statements | P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338 |
| WGK Germany | WGK 2 |
| Supplemental Hazard Statements | EUH019 |
| Density | 1.153 g/mL |