Synonym: 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one; 3′,4′,5,6,7,8-Hexamethoxyflavone
CAS Number: 478-01-3
Empirical Formula (Hill Notation): C21H22O8
Molecular Weight: 402.39
MDL Number: MFCD03273560
Linear Formula: C21H22O8
Product Type: Chemical
application(s) |
food and beverages |
assay |
≥98.0% (HPLC) |
format |
neat |
grade |
analytical standard |
impurities |
≤5.0% water |
InChI |
1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3 |
InChI key |
MRIAQLRQZPPODS-UHFFFAOYSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
shelf life |
limited shelf life, expiry date on the label |
SMILES string |
COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2 |
technique(s) |
gas chromatography (GC): suitable |
|
HPLC: suitable |
Application: |
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
Biochem/physiol Actions: |
Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98.0% (HPLC) |
UNSPSC |
85151701 |