Trimethylsulfonium hydroxide solution
SIAL/92732 - ~0.25 M in methanol, for GC derivatization, LiChropur™
Synonym: TMSH
CAS Number: 17287-03-5
Empirical Formula (Hill Notation): C3H10OS
Molecular Weight: 94.18
MDL Number: MFCD00216756
Linear Formula: (CH3)3S(OH)
Product Type: Chemical
| concentration | ~0.25 M in methanol |
| form | liquid |
| grade | for GC derivatization |
| InChI | 1S/C3H9S.H2O/c1-4(2)3;/h1 |
| InChI key | MDTPTXSNPBAUHX-UHFFFAOYSA |
| packaging | pkg of 10 × 1 mL |
| quality | LiChropur™ |
| Quality Level | 100  |
| reaction suitability | reagent type: derivatization reagent reaction type: Alkylations |
| SMILES string | [OH-].C[S+](C)C |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| Application: | TMSH solution has been used as a derivatizing agent in a study to determine the fatty acids in milk samples using thermochemolysis-gas chromatography-mass spectrometry. |
| General description: | Trimethylsulfonium hydroxide (TMSH) is a methylating reagent. It can be prepared by dissolving trimethylsulfonium iodide in methanol and water solvent further treating with silver oxide. |
| Legal Information: | LiChropur is a trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Reagent for the methylation of nucleophiles, e.g. carboxylic acids, alcohols, thiols, N-heterocycles; Rapid derivatization of acids for GC by pre-column transesterification of glycerides |
| Symbol |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H301 + H311 + H331 - H315 - H319 - H370 |
| Precautionary statements | P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 16-36/37-45 |
| RIDADR | UN 3286 8(6.1)(3) / PGII |
| WGK Germany | WGK 2 |
| Flash Point(F) | 51.8 °F - closed cup |
| Flash Point(C) | 11 °C - closed cup |
| Storage Temp. | 2-8°C |
| UNSPSC | 12000000 |