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Trizma® base

SIAL/93440 - reference material for titrimetry, certified by BAM, ≥99.5%

Synonym: 2-Amino-2-(hydroxymethyl)-1,3-propanediol; THAM; Tris base; Tris(hydroxymethyl)aminomethane; Trometamol

CAS Number: 77-86-1
Empirical Formula (Hill Notation): C4H11NO3
Molecular Weight: 121.14
EC Number: 201-064-4
MDL Number: MFCD00004679
Linear Formula: NH2C(CH2OH)3
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-93440-50G 50 g
$362.00
1/EA
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assay ≥99.5%
bp 219-220 °C/10 mmHg (lit.)
description aminopeptidase substrate
format neat
grade reference material
InChI 1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChI key LENZDBCJOHFCAS-UHFFFAOYSA-N
mp 167-172 °C (lit.)
pH 10.5-12
pKa (25 °C) 8.1
quality certified by BAM
Quality Level 100 
SMILES string NC(CO)(CO)CO
solubility water: soluble (678 g/l at 20 °C)
technique(s) titration: suitable
useful pH range 7-9
Analysis Note: Exact concentration, expiry date, traceability and detailed information on certification can be found on the certificate and certification report, included in each package. Content and expiry date on label.
Application: It finds its use as a reference material for the standardization of volumetric solutions in acidimetric titrations.
Features and Benefits: • Available as a solid in a secure glass bottle to ensure its stability for the entire shelf life until opened.
• High-purity material traceable to NIST SRM
• High-quality offering accurate titer determinations
• Accompanied by a certificate of analysis (CoA)
General description: Trizma® base is a volumetric standard produced under rigorous conditions and measured with the highest possible precision. Its content is determined by volumetric neutralization titration using a combined pH glass electrode. The certified value and uncertainty measurement of the standard are in accordance with ISO Guide 35.
Legal Information: Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.
For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99.5%
bp 219-220 °C/10 mmHg (lit.)
mp 167-172 °C (lit.)
UNSPSC 41116107

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