Everolimus

SIAL/94687 - analytical standard

Synonym: 42-O-(2-Hydroxyethyl)rapamycin

CAS Number: 159351-69-6
Empirical Formula (Hill Notation): C₅₃H₈₃NO₁₄
Molecular Weight: 958.22
MDL Number: MFCD00929329
Linear Formula: C₅₃H₈₃NO₁₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-94687-10MG	10 mg	$193.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	clinical testing
assay	≥75.0% (qNMR)
format	neat
grade	analytical standard
InChI	1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
InChI key	HKVAMNSJSFKALM-GKUWKFKPSA-N
Quality Level	100
shelf life	limited shelf life, expiry date on the label
SMILES string	O=C(C([C@@]1(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C2=O)([H])O1)=O)N3[C@H](C(O[C@@]([C@@H](C[C@@]4([H])C[C@@H](OC)[C@H](OCCO)CC4)C)([H])CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]2OC)=O)=O)CCCC3
storage temp.	−20°C

Application:	Everolimus may be used as a standard in the following clinical studies: • Investigation of its glucose-dependent growth-inhibitory property in breast cancer cell lines. • Evaluate its possible antiproliferative effects in human bronchial carcinoids in primary culture.
General description:	Everolimus (RAD001), a derivative of rapamycin, is commonly used as a drug for the inhibition of the mTOR pathway, affecting tumor cell division and angiogenesis.

Symbol	GHS08,GHS09
Signal word	Warning
Hazard statements	H351 - H361fd - H373 - H410
Precautionary statements	P201 - P260 - P273 - P280 - P308 + P313 - P391
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥75.0% (qNMR)
Storage Temp.	−20°C
UNSPSC	41116107

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