4-Hydroxytamoxifen
SIAL/94873 - (E) and (Z) isomers (50:50), analytical standard
Synonym: 4-
CAS Number: 68392-35-8
Empirical Formula (Hill Notation): C26H29NO2
Molecular Weight: 387.51
Linear Formula: C26H29NO2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 94873-10MG
| application(s) | forensics and toxicology pharmaceutical (small molecule) |
| assay | ≥97.5% (HPLC) |
| format | neat |
| grade | analytical standard |
| impurities | ≤5.0% water |
| InChI | 1S/2C26H29NO2/c2*1-4-25(2 |
| InChI key | ZJLDABGSDWXVGE-BDSXMVAQSA |
| Quality Level | 100  |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | CCC(c1ccccc1)=C(/c2ccc(O |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | 4-Hydroxytamoxifen may be used as a reference standard in the determination of 4-hydroxythmoxifen in plasma samples using high-performance liquid chromatography with fluorescence detection (HPLC). |
| Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| Biochem/physiol Actions: | Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation. |
| General description: | 4-Hydroxytamoxifen is a first generation, selective estrogen receptor modulator (SERM) that functions as an antagonist in breast cancer cells but can display estrogen-like activities in the uterus and bone. |
| Symbol |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302 + H312 + H332 - H361 |
| Precautionary statements | P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 63-20/21/22 |
| Safety Statements | 22-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.5% (HPLC) |
| UNSPSC | 41116107 |