Phosphonoacetic acid

SIAL/96708 - TraceCERT^®, ³¹P-qNMR Standard, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

CAS Number: 4408-78-0
Empirical Formula (Hill Notation): C₂H₅O₅P
Molecular Weight: 140.03
EC Number: 224-558-1
MDL Number: MFCD00004311
Linear Formula: (HO)₂P(O)CH₂CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-96708-1G	1 g	$184.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	cleaning products cosmetics flavors and fragrances food and beverages personal care pharmaceutical
form	solid
grade	TraceCERT^®
InChI	1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
InChI key	XUYJLQHKOGNDPB-UHFFFAOYSA-N
manufacturer/tradename	Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
mp	143-146 °C (lit.)
product line	TraceCERT^®
Quality Level	300
shelf life	limited shelf life, expiry date on the label
SMILES string	OC(=O)CP(O)(O)=O
technique(s)	qNMR: suitable

Application:	Enhancing Guide RNA Stability and Editing Yields: Phosphonoacetate modifications have been shown to significantly enhance the stability and editing efficiency of guide RNAs for Cas9-based genome editors. This development has profound implications in genetic engineering and therapeutic applications, where precision and stability are crucial (Ryan et al., 2023 ). Glomerular and Tubulointerstitial Nephropathy Study: Phosphonoacetic acid has been indirectly related to studies on kidney diseases such as glomerular and tubulointerstitial nephropathy, showcasing its potential relevance in medical research to understand and treat complex renal conditions (Pleško et al., 2021 ). Environmental Impact of Phosphonoacetate: Research on PMIDA-modified magnetic nanoparticles, including those related to phosphonoacetate, explores their application in liver MRI, indicating its utility in enhancing diagnostic imaging techniques and its potential environmental implications (Demin et al., 2018 ). CRISPR-Cas Specificity Improvement: Modifications including phosphonoacetate derivatives have been employed to improve the specificity and efficiency of CRISPR-Cas systems in gene editing, underscoring the chemical′s role in cutting-edge biotechnological research (Ryan et al., 2018 ). Cardiovascular Pharmacology: Studies involving phosphonoacetic acid have been connected to cardiovascular pharmacology, particularly in exploring the mechanisms that inhibit calcification in vascular tissues, which is vital for developing treatments for vascular calcification diseases (Duan et al., 2017 ).
General description:	This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com. Check out our entire range of quantitative NMR standards (qNMR standards)
Legal Information:	TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany
Recommended products:	Check out ChemisTwin, our brand new online portal for identity confirmation of NMR spectra. A feature for quantitative NMR is in development. Learn more or reach out to us for a free trial .

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	143-146 °C (lit.)
UNSPSC	41116107

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