Aurintricarboxylic acid ammonium salt
SIAL/A36883 - ACS reagent
Synonym: ATA; Aluminon; Ammonium aurintricarboxylate
CAS Number: 569-58-4
Empirical Formula (Hill Notation): C22H23N3O9
Molecular Weight: 473.43
EC Number: 209-319-1
MDL Number: MFCD00040925
Linear Formula: C22H14O9 · 3NH3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A36883-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A36883-25G
| λmax | 450 nm |
| 522 nm (2nd) | |
| application(s) | diagnostic assay manufacturing hematology histology |
| biological source | synthetic |
| form | powder or crystals |
| grade | ACS reagent |
| ign. residue | ≤0.2% |
| impurities | ≤0.1% insolubles |
| InChI | 1S/C22H14O9.3H3N/c23-16-4 |
| InChI key | AIPNSHNRCQOTRI-UHFFFAOYSA |
| mp | 220-225 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | N.N.N.OC(=O)c1cc(ccc1O)C |
| solubility | water: soluble 100 mg/mL |
| storage temp. | room temp |
| Application: | Reagent for aluminum |
| Biochem/physiol Actions: | Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis. |
| Other Notes: | May contain a substantial amount of polymeric material. |
| Packaging: | 25, 100 g in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 220-225 °C (dec.) (lit.) |
| Storage Temp. | room temp |
| Colour Index Number | 43810 |
| UNSPSC | 12171500 |