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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

SIAL/A8456 - ≥97.0% (HPLC)

Synonym: AEBSF

CAS Number: 30827-99-7
Empirical Formula (Hill Notation): C8H10FNO2S · HCl
Molecular Weight: 239.69
MDL Number: MFCD00132962
Linear Formula: C8H10FNO2S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A8456-25MG 25 mg
 $65.20
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45-A8456-100MG 100 mg
 $197.00
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45-A8456-500MG 500 mg
 $698.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8456-25MG

 

assay ≥97.0% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI key WRDABNWSWOHGMS-UHFFFAOYSA-N
mp 183-191  °C
Quality Level 300 
SMILES string FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl
solubility H2O: 50 mg/mL
storage temp. −20°C
Application: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) has been used:
• as a protease inhibitor in plasma samples to prevent acylated ghrelin (AG) degradation
• as a snake venom serine proteinase (SVSP) inhibitor in SVSP inhibition or AEBSF assay to test the involvement of SVSPs on the fibrinogen-clotting activity
• as a component in NP-40 lysis buffer to resuspend cell pellets for preparing cell lysates
Application: Recommended concentrations for use are 0.1-1 mM.
Biochem/physiol Actions: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) is an irreversible serine protease inhibitor. Inhibition constants are similar to those of phenylmethanesulfonyl fluoride (PMSF) and diisopropylfluorophosphate (DFP). AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein, and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water, and improved stability in aqueous solutions. AEBSF can be used in cell culture in concentrations of up to 0.25 mM.
Biochem/physiol Actions: AEBSF can inhibit acetylcholinesterase (AChE).
General description: stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.
Packaging: 25, 100, 500 mg in poly bottle
Purity ≥97.0% (HPLC)
mp 183-191  °C
Storage Temp. −20°C
UNSPSC 12352202

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