Ampicillin sodium salt
SIAL/A9518
Synonym: D-(−)-α-Aminobenzylpenicillin sodium salt
CAS Number: 69-52-3
Empirical Formula (Hill Notation): C16H18N3NaO4S
Molecular Weight: 371.39
EC Number: 200-708-1
MDL Number: MFCD00064313
Linear Formula: C16H18N3NaO4S
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: A9518-25G-9
This image depicts SKU: A9518-25G-9
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| application(s) | agriculture |
| biological source | synthetic (chemical) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C16H19N3O4S.Na/c1-16(2 |
| InChI key | KLOHDWPABZXLGI-YWUHCJSESA |
| mode of action | cell wall synthesis | interferes |
| mp | 215 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | [Na+].CC1(C)SC2[C@H](NC(= |
| solubility | water: 50 g/L |
| storage condition | ( |
| storage temp. | 2-8°C |
| Application: | Ampicillin sodium salt has been used: • to select for ampicillin resistance in mutated and transformed cells |
| Biochem/physiol Actions: | Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol. |
| Caution: | This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week. |
| Features and Benefits: | • High-quality antibiotic suitable for multiple research applications • Ideal for Cell Biology and Biochemical research. |
| General description: | Ampicillin sodium salt is a member of the extended-spectrum β-lactam family and a semisynthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall. Ampicillin sodium salt is active against a wide range of Gram-positive and Gram-negative bacteria, including E. coli, β-lactam-sensitive VRE, vancomycin-resistant Enterococcus species, Staphylococcus aureus, and Streptococcus pneumoniae. It is commonly used in research laboratories to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, and the selection and maintenance of recombinant plasmids in E. coli. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids |
| Packaging: | 5, 25, 100 g in in glass bottle |
| Preparation Note: | Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H317 - H334 |
| Precautionary statements | P261 - P280 - P342 + P311 |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 215 °C (dec.) (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352107 |