Ampicillin sodium salt
SIAL/A9518
Synonym: D-(−)-α-Aminobenzylpenicillin sodium salt
CAS Number: 69-52-3
Empirical Formula (Hill Notation): C16H18N3NaO4S
Molecular Weight: 371.39
EC Number: 200-708-1
MDL Number: MFCD00064313
Linear Formula: C16H18N3NaO4S
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
Gram-positive bacteria | |
application(s) | agriculture |
color | white to slight yellow |
form | powder |
InChI | 1S/C16H19N3O4S.Na/c1-16(2 |
InChI key | KLOHDWPABZXLGI-YWUHCJSESA |
mode of action | cell wall synthesis | interferes |
mp | 215 °C (dec.) (lit.) |
Quality Level | 200 ![]() |
SMILES string | [Na+].CC1(C)SC2[C@H](NC(= |
solubility | H2O: 50 mg/mL |
storage temp. | 2-8°C |
Application: | Used to select for ampicillin resistance in mutated and transformed cells. |
Biochem/physiol Actions: | Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol. |
Caution: | This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week. |
General description: | Chemical structure: ß-lactam |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids |
Packaging: | 5, 25, 100 g in in glass bottle |
Preparation Note: | Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months. |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H317 - H334 |
Precautionary statements | P261 - P280 - P342 + P311 |
Hazard Codes | Xn |
Risk Statements | 42/43 |
Safety Statements | 22-36/37-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
mp | 215 °C (dec.) (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 12352107 |