Butylhydroxytoluene

SIAL/B1215000 - European Pharmacopoeia (EP) Reference Standard

Synonym: 2,6-Di-tert-butyl-4-methylphenol; 2,6-Di-tert-butyl-p-cresol; BHT; Butylated hydroxytoluene; Butylhydroxytoluene; DBPC

CAS Number: 128-37-0
Empirical Formula (Hill Notation): C₁₅H₂₄O
Molecular Weight: 220.35
MDL Number: MFCD00011644
Linear Formula: [(CH₃)₃C]₂C₆H₂(CH₃)OH
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B1215000	120 mg	$251.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	cleaning products cosmetics food and beverages personal care pharmaceutical
autoignition temp.	878 °F
bp	265 °C (lit.)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
InChI key	NLZUEZXRPGMBCV-UHFFFAOYSA-N
manufacturer/tradename	EDQM
mp	69-73 °C (lit.)
SMILES string	Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
storage temp.	2-8°C
vapor density	7.6 (vs air)
vapor pressure	<0.01 mmHg ( 20 °C)

Application:	Multicomponent analysis of fat- and water-soluble vitamins and auxiliary substances in multivitamin preparations by qNMR.: This study utilizes Butylhydroxytoluene (BHT) as an auxiliary substance for its antioxidant properties in multivitamin preparations. The research demonstrates the effectiveness of BHT in maintaining the oxidative stability of vitamins, ensuring their longevity and efficacy in pharmaceutical applications (Eiff et al., 2015 ). Investigation of the stabilizing effects of antioxidants and benzophenone-3 on desonide photostability.: The study explores the use of BHT as an antioxidant to enhance the photostability of desonide. Findings indicate that BHT significantly improves the stability of the compound under light exposure, making it a valuable preservative in pharmaceutical and biotechnological formulations (Rosa et al., 2014 ). Understanding the molecular aspects of tetrahydrocannabinol and cannabidiol as antioxidants.: This research highlights BHT′s role as a comparative antioxidant in studying the properties of cannabinoids. BHT′s well-documented antioxidant mechanisms provide a benchmark for evaluating the efficacy of other compounds in oxidative stress research (Borges et al., 2013 ). Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants.: The kinetic analysis of BHT′s ability to quench singlet oxygen demonstrates its superior antioxidant capabilities compared to other synthetic antioxidants. This property is crucial for developing pharmaceutical formulations that require high oxidative stability (Kim et al., 2009 ).
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Sales restrictions may apply.
Packaging:	The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue .

Symbol	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point(F)	260.6 °F - open cup
Flash Point(C)	127 °C - open cup

bp	265 °C (lit.)
mp	69-73 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	41116107

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